| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
The primary target of isopropylparaben is microorganisms, including bacteria. The compound acts as an antimicrobial agent. Its mechanism of action involves disrupting microbial cell processes, inhibiting the growth of microorganisms. Isopropylparaben also exhibits antioxidant activity. The compound's preservative function is based on its antimicrobial properties.
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|---|---|
| ln Vitro |
In vitro studies have demonstrated the antimicrobial and antioxidant activities of isopropylparaben. The compound is effective against various bacteria. Isopropylparaben's antimicrobial activity has been characterized in standard microbiological assays. Its in vitro activity supports its use as a preservative in various products.
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| ln Vivo |
In vivo activity of isopropylparaben has not been extensively reported. The compound is primarily used as a preservative in cosmetic and pharmaceutical products. Animal model studies evaluating its in vivo effects have not been extensively published. Further studies are needed to fully characterize its in vivo biological activity.
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| Enzyme Assay |
For antimicrobial activity testing, standard agar diffusion or broth microdilution methods are used. Bacteria are cultured on appropriate media and exposed to serial dilutions of isopropylparaben. MIC values are determined after 24-48 hours of incubation. Standard protocols for antimicrobial preservative efficacy testing are described in the literature.
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| Cell Assay |
For in vitro cell-based studies, bacterial cells are cultured in appropriate media and treated with serial dilutions of isopropylparaben. Bacterial growth is assessed by measuring optical density or colony counting. The compound's antioxidant activity may be assessed using DPPH or other radical scavenging assays. Standard protocols for antimicrobial and antioxidant assays are described in the literature.
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| Animal Protocol |
In vivo animal studies for isopropylparaben have not been extensively reported. For similar paraben compounds, animal models may be used to evaluate safety and toxicity. The compound would be administered via oral or other routes. Standard protocols for in vivo toxicology studies can be adapted from the literature.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of isopropylparaben have been characterized. The compound has a LogP of 1.9574. It has a molecular weight of 180.20 g/mol. Specific PK parameters such as half-life and bioavailability have been reported in the literature. The compound is typically stored as a powder at -20°C for up to 3 years.
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| Toxicity/Toxicokinetics |
Toxicological data for isopropylparaben are available from regulatory assessments. As a paraben compound, it has been evaluated for safety in cosmetic and pharmaceutical applications. Standard toxicology studies have been conducted. The compound is considered safe for use as a preservative at approved concentrations.
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| References |
[1]. Stela Katavic, et al. In vitro assessment of the antioxidative, toxicological and antimicrobial properties of battery of parabens. Drug Chem Toxicol. 2023 Jun 19;1-10.
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| Additional Infomation |
Isopropyl p-hydroxybenzoate is a 4-hydroxybenzoate.
Isopropylparaben is a paraben-class antimicrobial preservative used in cosmetic products, personal care items, and pharmaceutical formulations. It is an antimicrobial and antioxidant agent. The compound is available as a research chemical for preservative and antimicrobial studies. No clinical or therapeutic applications have been reported. |
| Molecular Formula |
C10H12O3
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|---|---|
| Molecular Weight |
180.20
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| Exact Mass |
180.078
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| CAS # |
4191-73-5
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| Related CAS # |
Isopropyl 4-hydroxybenzoate-d4;1219798-72-7
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| PubChem CID |
20161
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| Appearance |
White to off-white solid
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
286.9±13.0 °C at 760 mmHg
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| Melting Point |
84-86°C
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| Flash Point |
120.4±12.6 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.530
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| LogP |
2.74
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
13
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| Complexity |
169
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O(C(C1C([H])=C([H])C(=C([H])C=1[H])O[H])=O)C([H])(C([H])([H])[H])C([H])([H])[H]
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| InChi Key |
CMHMMKSPYOOVGI-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H12O3/c1-7(2)13-10(12)8-3-5-9(11)6-4-8/h3-7,11H,1-2H3
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| Chemical Name |
propan-2-yl 4-hydroxybenzoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~554.9 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (27.75 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (27.75 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 5 mg/mL (27.75 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.5494 mL | 27.7469 mL | 55.4939 mL | |
| 5 mM | 1.1099 mL | 5.5494 mL | 11.0988 mL | |
| 10 mM | 0.5549 mL | 2.7747 mL | 5.5494 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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