| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vivo |
Ammonium lactate has the potential to help lessen the harmful effects of corticosteroids on the skin [3].
|
|---|---|
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
In vitro studies have shown that approximately 5.8% of the 12% ammonium lactate emulsion was absorbed after 68 hours via transdermal absorption using human cadaver skin. |
| References |
[1]. Robert J Anders, et al. Delaying Clostridium botulinum growth in fish and poultry with lactate salts. US4798729B1.
[2]. John Ademola, et al. Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. Am J Clin Dermatol. 2002;3(3):217-22. [3]. R M Lavker, et al. Effects of topical ammonium lactate on cutaneous atrophy from a potent topical corticosteroid. J Am Acad Dermatol. 1992 Apr;26(4):535-44. |
| Additional Infomation |
Ammonium lactate is a white solid or liquid, odorless, sinks to the bottom of water, and dissolves in water. (USCG, 1999)
Ammonium lactate is the ammonium salt of lactic acid. Ammonium lactate is an α-hydroxy acid. Ammonium lactate is an organic ammonium salt (made by neutralizing lactic acid with ammonium hydroxide) and is used as a topical moisturizer to treat ichthyosis vulgaris and xerosis. This drug is available in cream and lotion formulations to moisturize the skin and dissolve scales. (NCI04) It is a normal intermediate product in the fermentation (oxidation, metabolism) of sugars. The concentrated form is used orally to prevent gastrointestinal fermentation. (Excerpt from Stedman, 26th edition) See also: Lactic acid (containing active ingredient). Indications For the treatment of dry skin, scaling (xerosis), and ichthyosis vulgaris, and to provide temporary relief from itching associated with these conditions. FDA label Mechanism of actionUnknown. Pharmacodynamics Lactic acid is an alpha-hydroxy acid, a normal component of tissues and blood. Alpha-hydroxy acids (and their salts) can act as moisturizers when applied to the skin. This property may affect the moisture content of the stratum corneum. Furthermore, when lactic acid is applied to the skin, it may reduce the adhesion of keratinocytes. |
| Molecular Formula |
C3H9NO3
|
|---|---|
| Molecular Weight |
107.11
|
| Exact Mass |
107.058
|
| CAS # |
515-98-0
|
| PubChem CID |
62358
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.054 g/mL at 25 °C
|
| Boiling Point |
227.6ºC at 760mmHg
|
| Melting Point |
91-94ºC
|
| Flash Point |
109.9ºC
|
| Index of Refraction |
n20/D 1.363
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
7
|
| Complexity |
53.5
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(C(=O)O)O.N
|
| InChi Key |
RZOBLYBZQXQGFY-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C3H6O3.H3N/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);1H3
|
| Chemical Name |
azanium;2-hydroxypropanoate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : 125 mg/mL (1167.02 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.3362 mL | 46.6810 mL | 93.3620 mL | |
| 5 mM | 1.8672 mL | 9.3362 mL | 18.6724 mL | |
| 10 mM | 0.9336 mL | 4.6681 mL | 9.3362 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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