| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| 100mg | |||
| Other Sizes |
| Targets |
98N12-5 targets the delivery of siRNA to the liver. It is an ionizable lipid used in lipid nanoparticles (LNPs) for siRNA delivery. The lipid facilitates the encapsulation and delivery of siRNA to hepatocytes in the liver. It is a novel multi-tail ionizable lipid.
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|---|---|
| ln Vitro |
In vitro, 98N12-5 is used as an ionizable lipid in LNPs for siRNA delivery. It is used in combination with other lipids to form LNPs. The LNPs are used for efficient delivery of siRNA.
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| ln Vivo |
In vivo, 98N12-5 is used for efficient siRNA delivery to the liver. LNPs containing 98N12-5 are used for siRNA delivery. The lipid enables efficient delivery of siRNA to hepatocytes.
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| Enzyme Assay |
There are no in vitro enzyme/receptor binding assays for 98N12-5 as it is a lipid for RNA delivery, not an enzyme inhibitor. Its function is assessed by its ability to deliver siRNA into cells.
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| Cell Assay |
In vitro cell-based assays for 98N12-5 involve formulating the lipid into LNPs with siRNA and treating cells with the LNPs. siRNA delivery efficiency is assessed by measuring the knockdown of target genes. Cell viability and toxicity are also evaluated.
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| Animal Protocol |
In vivo animal studies for 98N12-5 involve administering 98N12-5 LNPs containing siRNA to mice via intravenous injection. siRNA delivery to the liver is assessed by measuring target gene knockdown in liver tissue.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 98N12-5 are not extensively detailed in the available literature. For storage, it should be kept at -20°C.
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| Toxicity/Toxicokinetics |
No specific toxicity data for 98N12-5 are available in the provided literature. The compound is for research use only. Standard laboratory safety precautions should be followed when handling.
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| References | |
| Additional Infomation |
98N12-5 is a novel ionizable lipid for efficient in vivo siRNA delivery to the liver. It is used in LNPs for siRNA delivery. Its CAS number is 917572-74-8.
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| Molecular Formula |
C81H163N9O5
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|---|---|
| Molecular Weight |
1343.22
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| Exact Mass |
1342.277
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| CAS # |
917572-74-8
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| PubChem CID |
16006000
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
24.1
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| Hydrogen Bond Donor Count |
6
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
79
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| Heavy Atom Count |
95
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| Complexity |
1560
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C(NCCCCCCCCCCCC)(=O)CCN(CCC(NCCCCCCCCCCCC)=O)CCN(CCC(NCCCCCCCCCCCC)=O)CCNCCN(CCC(NCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCC)=O
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| InChi Key |
HXVVOLDXHIMZJZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C81H163N9O5/c1-6-11-16-21-26-31-36-41-46-51-61-83-77(91)56-68-88(69-57-78(92)84-62-52-47-42-37-32-27-22-17-12-7-2)73-66-82-67-74-90(72-60-81(95)87-65-55-50-45-40-35-30-25-20-15-10-5)76-75-89(70-58-79(93)85-63-53-48-43-38-33-28-23-18-13-8-3)71-59-80(94)86-64-54-49-44-39-34-29-24-19-14-9-4/h82H,6-76H2,1-5H3,(H,83,91)(H,84,92)(H,85,93)(H,86,94)(H,87,95)
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| Chemical Name |
3-[2-[2-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]ethylamino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]-N-dodecylpropanamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~37.22 mM)
THF : 50 mg/mL (~37.22 mM) |
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.7445 mL | 3.7224 mL | 7.4448 mL | |
| 5 mM | 0.1489 mL | 0.7445 mL | 1.4890 mL | |
| 10 mM | 0.0744 mL | 0.3722 mL | 0.7445 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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