| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
6-Chloro-L-tryptophan does not have a defined pharmacological target. It is a halogenated amino acid analog used as a research tool. As a substrate for KtzQ, it is used to study the activity and specificity of this enzyme. At concentrations up to 500 μM, it exhibits no inhibitory effect on D-amino acid oxidase (DAO).
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| ln Vitro |
6-Chloro-L-tryptophan (0-500 μM) does not inhibit D-amino acid oxidase (DAO) [2].
In vitro, 6-Chloro-L-tryptophan is used as a substrate for KtzQ. It has no inhibitory effect on D-amino acid oxidase at concentrations up to 500 μM. Specific activity data, such as IC50 values, are not applicable as it is a substrate rather than an inhibitor. Its utility is demonstrated through its use in enzymatic assays studying KtzQ activity. |
| ln Vivo |
In vivo activity data are not available for 6-Chloro-L-tryptophan as it is not a drug candidate. It is a research chemical used in enzymatic studies.
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| Enzyme Assay |
A cell-free assay for 6-Chloro-L-tryptophan would involve measuring its utilization as a substrate by KtzQ. In this assay, the enzyme is incubated with the compound, and the product of the reaction is measured. The compound's purity and identity are typically confirmed by HPLC and other analytical methods.
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| Cell Assay |
Cellular experiments with 6-Chloro-L-tryptophan are not typical, as it is used as a substrate in biochemical assays rather than in cell-based studies. Its primary application is in studying the enzyme KtzQ.
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| Animal Protocol |
In vivo animal experiments for 6-Chloro-L-tryptophan are not applicable as it is not a therapeutic agent.
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| ADME/Pharmacokinetics |
6-Chloro-L-tryptophan has a molecular formula of C11H11ClN2O2 and a molecular weight of 238.67 g/mol. Its CAS number is 33468-35-8. It is a solid. It is soluble in water at 30 mg/mL with ultrasonic and warming and adjustment of pH to 12 with 1M NaOH. Specific pharmacokinetic properties are not applicable as it is not a therapeutic drug.
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| Toxicity/Toxicokinetics |
Toxicity data for 6-Chloro-L-tryptophan are not provided in the available sources. As a halogenated amino acid derivative, it should be handled with standard laboratory safety precautions. It is intended for research use only and is not for human consumption.
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| References |
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| Additional Infomation |
6-Chloro-L-tryptophan is a non-protein L-α-amino acid, a derivative of L-tryptophan in which the hydrogen atom at the 6-position of the indole ring is replaced by a chlorine atom. It is a non-protein L-α-amino acid, an L-tryptophan derivative, and an organochlorine compound. It is the zwitterion tautomer of 6-chloro-L-tryptophan.
6-Chloro-L-tryptophan (CAS: 33468-35-8) is a chlorinated derivative of L-tryptophan. It is also known as 6-Chloro L-Tryptophan. The compound is used as a substrate for the enzyme KtzQ. It is not a therapeutic drug and is strictly for research purposes. |
| Molecular Formula |
C11H11N2O2CL
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|---|---|
| Molecular Weight |
238.67024
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| Exact Mass |
238.05
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| CAS # |
33468-35-8
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| PubChem CID |
10062693
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| Appearance |
White to gray solid powder
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| Density |
1.5±0.1 g/cm3
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| Boiling Point |
476.9±45.0 °C at 760 mmHg
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| Melting Point |
244-246ºC
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| Flash Point |
242.2±28.7 °C
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| Vapour Pressure |
0.0±1.3 mmHg at 25°C
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| Index of Refraction |
1.702
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| LogP |
1.63
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
16
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| Complexity |
275
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C1=CC2=C(C=C1Cl)NC=C2C[C@@H](C(=O)O)N
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| InChi Key |
FICLVQOYKYBXFN-VIFPVBQESA-N
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| InChi Code |
InChI=1S/C11H11ClN2O2/c12-7-1-2-8-6(3-9(13)11(15)16)5-14-10(8)4-7/h1-2,4-5,9,14H,3,13H2,(H,15,16)/t9-/m0/s1
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| Chemical Name |
(2S)-2-amino-3-(6-chloro-1H-indol-3-yl)propanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~50 mg/mL (~209.49 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1899 mL | 20.9494 mL | 41.8989 mL | |
| 5 mM | 0.8380 mL | 4.1899 mL | 8.3798 mL | |
| 10 mM | 0.4190 mL | 2.0949 mL | 4.1899 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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