| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg | |||
| 10g |
|
||
| Other Sizes |
| Targets |
4-Hydroxycyclohexanecarboxylic acid does not have a specific pharmacological target. It may be used as a synthetic intermediate for the preparation of pharmaceutical compounds. Its structural similarity to GHB suggests potential interaction with GABA receptors, but this is not well documented.
|
|---|---|
| ln Vitro |
In vitro activity is not well characterized for this compound. It is primarily used as a chemical intermediate rather than a pharmacologically active agent. It may serve as a reference standard in analytical chemistry for the detection of related compounds.
|
| ln Vivo |
In vivo activity is not documented for 4-hydroxycyclohexanecarboxylic acid. It is not a therapeutic agent and is not used in animal models for pharmacological studies.
|
| Enzyme Assay |
4-Hydroxycyclohexanecarboxylic acid can be analyzed by HPLC or GC-MS. For use as a synthetic intermediate, standard organic chemistry reaction protocols are employed. It can be esterified, amidated, or reduced to the corresponding alcohol.
|
| Cell Assay |
Cell-based assays are not applicable for this compound as it is not a pharmacologically active agent. It may be used in cytotoxicity screening as a negative control or in metabolism studies as a reference compound.
|
| Animal Protocol |
Animal studies are not applicable for 4-hydroxycyclohexanecarboxylic acid as it is not a therapeutic agent. It is not administered to animals for pharmacological evaluation.
|
| ADME/Pharmacokinetics |
4-Hydroxycyclohexanecarboxylic acid (MW 144.17) is a small hydrophilic molecule. As a chemical intermediate, pharmacokinetic properties are not studied. It is not intended for therapeutic use.
|
| Toxicity/Toxicokinetics |
4-Hydroxycyclohexanecarboxylic acid is considered to have low toxicity as a chemical intermediate. Standard laboratory safety precautions should be taken. Comprehensive toxicological data are not available.
|
| Additional Infomation |
4-Hydroxycyclohexanecarboxylic acid is a 4-hydroxy monocarboxylic acid with a cyclohexane structure, where a carboxyl group is substituted at the 1-position and a hydroxyl group is substituted at the 4-position. It is a human urinary metabolite and is functionally related to cyclohexanecarboxylic acid. Trans-4-hydroxycyclohexanecarboxylic acid has also been reported in hemlock (Tsuga dumosa), and relevant data are available.
4-Hydroxycyclohexanecarboxylic acid is a research chemical used as a building block in organic synthesis and as a reference standard. It is not a drug and is not in clinical trials. It may be used in the synthesis of pharmaceutical compounds and other biologically active molecules. |
| Molecular Formula |
C7H12O3
|
|---|---|
| Molecular Weight |
144.1684
|
| Exact Mass |
144.078
|
| CAS # |
17419-81-7
|
| PubChem CID |
151138
|
| Appearance |
White to light yellow solid powder
|
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
307.9±35.0 °C at 760 mmHg
|
| Flash Point |
154.2±22.4 °C
|
| Vapour Pressure |
0.0±1.5 mmHg at 25°C
|
| Index of Refraction |
1.523
|
| LogP |
0.07
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
10
|
| Complexity |
125
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1CC(CCC1C(=O)O)O
|
| InChi Key |
HCFRWBBJISAZNK-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)
|
| Chemical Name |
4-hydroxycyclohexane-1-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.9363 mL | 34.6813 mL | 69.3626 mL | |
| 5 mM | 1.3873 mL | 6.9363 mL | 13.8725 mL | |
| 10 mM | 0.6936 mL | 3.4681 mL | 6.9363 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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