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| Other Sizes |
| Targets |
3-Aminobutanoic acid targets plant defense signaling pathways. It primes the plant immune system, leading to enhanced resistance against pathogens. The compound's mechanism involves the activation of defense-related genes and the accumulation of pathogenesis-related proteins. It may also induce systemic acquired resistance (SAR) in plants.
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| ln Vitro |
3-Aminobutanoic acid demonstrates in vitro activity as a plant defense inducer. It primes plant defense responses, leading to enhanced resistance against bacterial, fungal, and viral pathogens. The compound's activity is assessed in plant models by measuring disease resistance and the expression of defense-related genes.
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| ln Vivo |
In vivo activity of 3-aminobutanoic acid has been demonstrated in plant models, where it provides protection against a wide range of pathogens. The compound is used as a plant defense inducer in agricultural research. Its ability to prime plant immune responses makes it a valuable tool for studying plant-pathogen interactions.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for 3-aminobutanoic acid are not typically performed, as the compound's mechanism involves plant defense signaling rather than specific enzyme inhibition. Its activity is assessed in plant models by measuring disease resistance and defense gene expression.
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| Cell Assay |
In vitro cellular assays for 3-aminobutanoic acid are not typically performed, as the compound is a plant defense inducer. Its activity is assessed in plant tissue or whole-plant models by measuring disease resistance, defense gene expression, and accumulation of defense-related metabolites.
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| Animal Protocol |
In vivo animal experiments for 3-aminobutanoic acid are not applicable, as the compound is a plant defense inducer used in agricultural research. It is not intended for animal studies.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 3-aminobutanoic acid are limited. The compound is used in plant research as a defense inducer. Its uptake, distribution, and metabolism in plants have been studied in the context of plant immunity. The compound is for research use only.
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| Toxicity/Toxicokinetics |
Toxicological data for 3-aminobutanoic acid are limited. As a non-proteinogenic amino acid, it is generally considered to have low toxicity. The compound is intended for research use only. Standard laboratory safety precautions should be followed when handling this compound.
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| References |
[1]. Cohen, et al. Local and systemic control of Phytophthora infestans in tomato with DL-3-aminobutanoic acid. Phytopathology. Volume: 84. Issue: 1. Pages: 55-9. Journal
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| Additional Infomation |
3-Aminobutyric acid (3-aminobutyric acid) is a β-amino acid formed by substituting an amino group at the 3-position of butyric acid. It is a metabolite. It is both a β-amino acid and a monocarboxylic acid. Functionally, it is related to butyric acid. It is the conjugate acid of 3-aminobutyric acid. It is the zwitterion tautomer of 3-aminobutyric acid.
3-Aminobutanoic acid (CAS#: 541-48-0) has the molecular formula C4H9NO2 and a molecular weight of 103.12. It is a non-proteinogenic amino acid that acts as a plant defense inducer. The compound primes plant defense responses, providing protection against bacterial, fungal, and viral pathogens. It is for research use only. |
| Molecular Formula |
C4H9NO2
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|---|---|
| Molecular Weight |
103.12
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| Exact Mass |
103.063
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| CAS # |
541-48-0
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| PubChem CID |
10932
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
223.6±23.0 °C at 760 mmHg
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| Melting Point |
189 °C (dec.)(lit.)
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| Flash Point |
89.0±22.6 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.462
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| LogP |
-0.51
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
7
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| Complexity |
72.1
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C(C([H])([H])C([H])(C([H])([H])[H])N([H])[H])=O
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| InChi Key |
OQEBBZSWEGYTPG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C4H9NO2/c1-3(5)2-4(6)7/h3H,2,5H2,1H3,(H,6,7)
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| Chemical Name |
3-aminobutanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : 25 mg/mL (242.44 mM)
DMSO : 1.96 mg/mL (19.01 mM) |
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.6974 mL | 48.4872 mL | 96.9744 mL | |
| 5 mM | 1.9395 mL | 9.6974 mL | 19.3949 mL | |
| 10 mM | 0.9697 mL | 4.8487 mL | 9.6974 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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