| Size | Price | Stock | Qty |
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| 5g |
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| 10g |
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| 25g | |||
| Other Sizes |
| Targets |
2-(Naphthalen-1-yl)-5-phenyloxazole does not have a specific pharmacological target as it is a fluorescent dye. Its function is to absorb light and emit fluorescence, which can be used to detect and visualize biological molecules or processes. The compound's structure contains a nitrogen atom that can interfere with the nitrogen content from the amination step, suggesting it may interact with amines. However, its primary application is as a fluorescent probe in analytical and research settings.
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| ln Vitro |
In vitro, 2-(Naphthalen-1-yl)-5-phenyloxazole is used as a fluorescent dye. It is suitable for scintillation spectrometry and is used in laser-grade applications. The compound's fluorescence properties make it useful for detecting and quantifying analytes in various assays. Its nitrogen atom can interfere with the nitrogen content from the amination step, which may be a consideration in certain analytical procedures. The compound is typically used in organic solvents due to its hydrophobic nature.
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| ln Vivo |
Specific in vivo activity data for 2-(Naphthalen-1-yl)-5-phenyloxazole are not detailed in the available literature. The compound is a fluorescent dye used primarily for in vitro applications, such as scintillation spectrometry and as a fluorescent probe. It is not used as a therapeutic agent and does not have a known pharmacological activity in vivo. Its use in biological systems would be limited to applications such as labeling or tracing, rather than exerting a biological effect.
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| Enzyme Assay |
In vitro experiments with 2-(Naphthalen-1-yl)-5-phenyloxazole typically involve its use as a fluorescent dye or scintillator. For fluorescence measurements, the compound is dissolved in an appropriate organic solvent (e.g., ethanol, toluene) and its fluorescence is measured using a spectrophotometer or fluorometer with suitable excitation and emission wavelengths. For scintillation spectrometry, the compound is dissolved in a scintillation cocktail, and the radioactivity of a sample is measured by detecting the light pulses generated upon interaction with ionizing radiation. The compound's concentration and purity are verified using standard analytical techniques.
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| Cell Assay |
Cell-based assays using 2-(Naphthalen-1-yl)-5-phenyloxazole are not typical, as the compound is a fluorescent dye used primarily in analytical applications. It is not generally used as a probe for live-cell imaging due to its hydrophobic nature and potential for non-specific binding. However, it could be used to stain fixed cells or tissue sections if appropriate protocols are developed. The compound's use is primarily in in vitro analytical settings.
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| Animal Protocol |
Specific in vivo animal experiment protocols for 2-(Naphthalen-1-yl)-5-phenyloxazole are not detailed in the available literature. The compound is a fluorescent dye and is not typically administered to animals for therapeutic or imaging purposes. Its use in vivo would be limited, as it is not water-soluble and may have toxicity concerns. If used, it would likely be formulated in an organic solvent or emulsion for administration, but this is not a standard application.
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| ADME/Pharmacokinetics |
2-(Naphthalen-1-yl)-5-phenyloxazole has a molecular weight of 271.31 g/mol and the formula C19H13NO. It is also known as α-NPO, 2-(1-naphthyl)-5-phenyloxazole, and α-naphthylphenyloxazole. The compound is a laser-grade dye suitable for scintillation spectrometry. It is typically stored at room temperature, protected from light. Its purity is typically ≥99%. The compound's fluorescence properties make it useful for various analytical applications.
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| Toxicity/Toxicokinetics |
Specific toxicological data for 2-(Naphthalen-1-yl)-5-phenyloxazole are not provided in the available sources. As a research chemical, its safety profile in humans has not been established. The compound is classified as a research reagent and is not for therapeutic or veterinary use. Standard laboratory safety precautions should be followed when handling this compound, including the use of appropriate personal protective equipment. Its purity is typically ≥98% or higher.
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| References | |
| Additional Infomation |
2-(Naphthalen-1-yl)-5-phenyloxazole, also known as α-NPO, is an organic fluorescent dye. It has the molecular formula C19H13NO and a molecular weight of 271.31 g/mol. The compound features an oxazole ring substituted with naphthyl and phenyl groups at the 2 and 5 positions, respectively. It is a laser-grade compound suitable for scintillation spectrometry. The dye is used in research applications requiring fluorescence detection. It is also known by other names, including 2-(1-naphthyl)-5-phenyloxazole and α-naphthylphenyloxazole. The compound is intended for research use only and is not for human consumption.
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| Molecular Formula |
C19H13NO
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|---|---|
| Molecular Weight |
271.3126
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| Exact Mass |
271.1
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| CAS # |
846-63-9
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| PubChem CID |
70058
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.178g/cm3
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| Boiling Point |
451ºC at 760 mmHg
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| Melting Point |
104-106 °C
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| Flash Point |
192.6ºC
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| Index of Refraction |
1.647
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| LogP |
5.161
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
21
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| Complexity |
339
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
WWVFJJKBBZXWFV-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H13NO/c1-2-8-15(9-3-1)18-13-20-19(21-18)17-12-6-10-14-7-4-5-11-16(14)17/h1-13H
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| Chemical Name |
2-naphthalen-1-yl-5-phenyl-1,3-oxazole
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~184.29 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6858 mL | 18.4291 mL | 36.8582 mL | |
| 5 mM | 0.7372 mL | 3.6858 mL | 7.3716 mL | |
| 10 mM | 0.3686 mL | 1.8429 mL | 3.6858 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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