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| Other Sizes |
| Targets |
2-Amino-2-methyl-1,3-propanediol does not have a biological target. It is a chemical compound used as a biological buffer and as an intermediate in the synthesis of various products. Its buffering capacity is based on its chemical properties as an amino alcohol, which can accept or donate protons to maintain pH in a desired range. It acts as an absorbent for acidic gases.
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| ln Vitro |
In vitro, 2-Amino-2-methyl-1,3-propanediol is used as a biological buffer and as a spacer in isotachophoresis of proteins. It is also used in the synthesis of surface-active agents, vulcanization accelerators, and pharmaceuticals. Its utility in these applications stems from its chemical properties rather than any pharmacological activity.
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| ln Vivo |
In vivo applications of 2-Amino-2-methyl-1,3-propanediol are not typical, as it is primarily an industrial chemical and laboratory reagent. It is not administered to living organisms for therapeutic purposes. Its use is confined to industrial and laboratory settings.
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| Enzyme Assay |
A cell-free assay for 2-Amino-2-methyl-1,3-propanediol is not applicable as it is not an enzyme inhibitor or receptor ligand. Its properties as a buffer can be characterized by measuring its pKa and buffering capacity in aqueous solutions. Its purity (>98.0%) is typically confirmed by GC and titration.
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| Cell Assay |
Cellular experiments with 2-Amino-2-methyl-1,3-propanediol are not typical, as it is used as a buffer and chemical intermediate rather than a pharmacologically active compound.
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| Animal Protocol |
In vivo animal experiments for 2-Amino-2-methyl-1,3-propanediol are not applicable as it is not a therapeutic agent.
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| ADME/Pharmacokinetics |
2-Amino-2-methyl-1,3-propanediol has a molecular formula of C4H11NO2 and a molecular weight of 105.14 g/mol. It is a white crystalline solid. Its CAS number is 115-69-5. The compound has a purity of ≥99%. Specific pharmacokinetic properties are not applicable as it is not a therapeutic drug.
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| Toxicity/Toxicokinetics |
Toxicity data for 2-Amino-2-methyl-1,3-propanediol are not provided in the available sources. As a chemical reagent, it should be handled with appropriate safety precautions. It is intended for research and industrial use and is not for human consumption.
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| Additional Infomation |
2-Amino-2-methylpropane-1,3-diol is an amino diol formed by replacing the amino and methyl groups at the 2-position of propane-1,3-diol. 2-Amino-2-methyl-1,3-propanediol is a metabolite found or produced in Saccharomyces cerevisiae.
2-Amino-2-methyl-1,3-propanediol (CAS: 115-69-5) is an organic compound also known as AMPD. It is used as a biological buffer, a spacer in isotachophoresis, and as an intermediate in the synthesis of surfactants, vulcanization accelerators, and pharmaceuticals. It is not a therapeutic drug and is strictly for research and industrial purposes. |
| Molecular Formula |
C4H11NO2
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|---|---|
| Molecular Weight |
105.1356
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| Exact Mass |
105.078
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| CAS # |
115-69-5
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| PubChem CID |
1531
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| Appearance |
White to off-white solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
271.5±0.0 °C at 760 mmHg
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| Melting Point |
100-110 °C(lit.)
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| Flash Point |
109.7±21.8 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.494
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| LogP |
-1.16
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
7
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| Complexity |
51.7
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])O[H])N([H])[H]
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| InChi Key |
UXFQFBNBSPQBJW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C4H11NO2/c1-4(5,2-6)3-7/h6-7H,2-3,5H2,1H3
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| Chemical Name |
2-amino-2-methylpropane-1,3-diol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.5111 mL | 47.5556 mL | 95.1113 mL | |
| 5 mM | 1.9022 mL | 9.5111 mL | 19.0223 mL | |
| 10 mM | 0.9511 mL | 4.7556 mL | 9.5111 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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