| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
1,3-Dioleoyl-2-palmitoylglycerol does not have a specific protein target but functions as a dietary lipid. As a triglyceride, it is a major component of human milk fat and is incorporated into infant formulas to mimic the lipid profile of breast milk. Its structure, with palmitic acid at the sn-2 position, is thought to be important for efficient fat and calcium absorption in infants. The compound's role is primarily nutritional rather than pharmacological, serving as a source of energy and essential fatty acids.
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| ln Vitro |
In vitro, 1,3-Dioleoyl-2-palmitoylglycerol is used as a reference standard and in formulation studies for infant formula and lipid nutrition research. Its physical and chemical properties, including its melting point (19°C) and density (0.919 g/cm³), are characterized for quality control. The compound is not typically used in pharmacological activity assays but rather in studies of lipid digestion, absorption, and metabolism.
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| ln Vivo |
In vivo, 1,3-Dioleoyl-2-palmitoylglycerol is a dietary lipid that is digested and absorbed in the gastrointestinal tract. As a component of infant formula, it provides a source of energy and essential fatty acids for growth and development. The compound's presence in human milk and its use in formula aim to support optimal fat and calcium absorption. However, the compound is not administered as a therapeutic agent but as a nutritional ingredient.
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| Enzyme Assay |
The in vitro assays for 1,3-Dioleoyl-2-palmitoylglycerol typically involve lipid analysis and formulation characterization. The compound is analyzed by HPLC, GC, or LC-MS to determine purity and fatty acid composition. For formulation studies, the compound is incorporated into lipid emulsions, and the stability, droplet size distribution, and oxidative stability are assessed using standard methods. All experiments include appropriate controls (reference standards) and are performed in triplicate.
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| Cell Assay |
For in vitro cellular assays, 1,3-Dioleoyl-2-palmitoylglycerol is not typically used as a pharmacologically active compound. It may be used in studies of lipid metabolism in cell culture, where cells (e.g., intestinal epithelial cells, adipocytes) are treated with the triglyceride at concentrations ranging from 1 to 100 µM for 24-72 hours. Cellular lipid uptake, metabolism, and gene expression related to lipid homeostasis may be assessed. However, specific protocols are not well-documented.
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| Animal Protocol |
For in vivo studies, 1,3-Dioleoyl-2-palmitoylglycerol is not typically administered to animals as a therapeutic agent. It is used in nutritional studies, where it is incorporated into the diet of animal models to study lipid metabolism, growth, and development. The compound is also used in infant formula studies to assess its effects on fat and calcium absorption. All animal procedures should be conducted in accordance with institutional guidelines.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of 1,3-Dioleoyl-2-palmitoylglycerol are not relevant, as it is a dietary lipid rather than a therapeutic agent. Following ingestion, the compound is digested by lipases in the gastrointestinal tract, releasing free fatty acids and monoglycerides that are absorbed and metabolized. The compound is not typically characterized for pharmacokinetic parameters such as half-life or bioavailability, as it is a nutritional component.
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| Toxicity/Toxicokinetics |
The toxicology of 1,3-Dioleoyl-2-palmitoylglycerol has been evaluated in the context of its use as a food ingredient. As a triglyceride found in human milk and used in infant formula, it is generally recognized as safe for its intended nutritional use. No significant toxicity or adverse effects are reported at typical dietary levels. The compound is not genotoxic or carcinogenic. It is available for research use and is not approved as a therapeutic agent.
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| References | |
| Additional Infomation |
1,3-Dioleoyl-2-palmitoylglycerol is a triglyceride in which the acyl groups at positions 1 and 3 are oleoyl groups, and the acyl group at position 2 is a palmitoyl group. Functionally, it is associated with hexadecanoic acid and oleic acid. It has been reported that 1,3-dioleoyl-2-palmitoylglycerol is present in the Japanese aphid (Lysiphlebia japonica) and the cotton aphid (Aphis gossypii), and relevant data are available.
1,3-Dioleoyl-2-palmitoylglycerol is a significant triacylglycerol incorporated in infant formulas. It has a molecular formula of C55H102O6 and a molecular weight of 859.39. The compound is not approved as a therapeutic agent but is widely used as a nutritional ingredient in infant formula and lipid research. It is available as a high-purity research reagent for laboratory use. |
| Molecular Formula |
C55H102O6
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|---|---|
| Molecular Weight |
859.39478
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| Exact Mass |
858.768
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| CAS # |
1716-07-0
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| PubChem CID |
13183955
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.919g/cm3
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| Boiling Point |
802.2ºC at 760 mmHg
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| Melting Point |
19°C (lit.)
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| Flash Point |
298.4ºC
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| Vapour Pressure |
9.37E-26mmHg at 25°C
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| Index of Refraction |
1.473
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| LogP |
17.54
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
52
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| Heavy Atom Count |
61
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| Complexity |
933
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCCCC/C=C/CCCCCCCC(OCC(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCC/C=C/CCCCCCCC)=O)=O
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| InChi Key |
PPTGNVIVNZLPPS-LBXGSASVSA-N
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| InChi Code |
InChI=1S/C55H102O6/c1-4-7-10-13-16-19-22-25-27-30-32-35-38-41-44-47-53(56)59-50-52(61-55(58)49-46-43-40-37-34-29-24-21-18-15-12-9-6-3)51-60-54(57)48-45-42-39-36-33-31-28-26-23-20-17-14-11-8-5-2/h25-28,52H,4-24,29-51H2,1-3H3/b27-25-,28-26-
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| Chemical Name |
[2-hexadecanoyloxy-3-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~116.36 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.1636 mL | 5.8181 mL | 11.6362 mL | |
| 5 mM | 0.2327 mL | 1.1636 mL | 2.3272 mL | |
| 10 mM | 0.1164 mL | 0.5818 mL | 1.1636 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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