| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| Other Sizes |
| Targets |
The compound targets bacterial cellular processes, exhibiting antibacterial activity. As an acridone alkaloid, it may interact with bacterial enzymes or disrupt bacterial membrane function. The specific molecular target has not been fully characterized in the available literature.
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|---|---|
| ln Vitro |
In vitro, 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one has demonstrated antibacterial activity. The compound is a natural product isolated from Zanthoxylum species. Detailed antibacterial activity data, including specific MIC values and bacterial strains tested, are limited in the available literature.
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| ln Vivo |
In vivo data for 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one are not available in the searched literature. The compound is a natural product that has been studied primarily for its in vitro antibacterial properties. Further in vivo studies are needed to evaluate its therapeutic potential.
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| Enzyme Assay |
The compound's mechanism of action has not been extensively characterized in the available literature. As an acridone alkaloid, it may exert antibacterial effects through inhibition of bacterial enzymes or disruption of membrane integrity. Detailed receptor-binding or enzyme inhibition studies have not been reported.
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| Cell Assay |
In vitro antibacterial assays using 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one typically involve testing the compound against various bacterial strains using standard broth microdilution or agar diffusion methods. The minimum inhibitory concentration (MIC) is determined to assess antibacterial activity.
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| Animal Protocol |
In vivo animal studies using 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one have not been reported in the available literature. The compound is primarily studied for its in vitro antibacterial properties.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one are not available in the searched literature. As a natural product, its absorption, distribution, metabolism, and excretion properties have not been characterized.
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| Toxicity/Toxicokinetics |
Toxicological data for 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one are not available in the searched literature. The compound is a natural product from Zanthoxylum species. As a research compound, it is intended for laboratory use only and not for human consumption.
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| Additional Infomation |
According to reports, Micromelum integerrimum contains 1,3-dihydroxy-4-methoxy-10-methylacridin-9(10H)-one, and there is relevant data.
1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one has a molecular formula of C₁₅H₁₃NO₄ and a molecular weight of 271.27. It is an acridone alkaloid compound with antibacterial activity. The compound is isolated from the fruits of Zanthoxylum leprieurii and Zanthoxylum zanthoxyloides. |
| Molecular Formula |
C15H13NO4
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|---|---|
| Molecular Weight |
271.26802
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| Exact Mass |
271.084
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| CAS # |
1189362-86-4
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| PubChem CID |
44179836
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
510.9±50.0 °C at 760 mmHg
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| Flash Point |
262.8±30.1 °C
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| Vapour Pressure |
0.0±1.4 mmHg at 25°C
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| Index of Refraction |
1.670
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| LogP |
2.44
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
20
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| Complexity |
388
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CN1C2=CC=CC=C2C(=O)C3=C1C(=C(C=C3O)O)OC
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| InChi Key |
YIBYVKSDVRSLGT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H13NO4/c1-16-9-6-4-3-5-8(9)14(19)12-10(17)7-11(18)15(20-2)13(12)16/h3-7,17-18H,1-2H3
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| Chemical Name |
1,3-dihydroxy-4-methoxy-10-methylacridin-9-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6864 mL | 18.4318 mL | 36.8636 mL | |
| 5 mM | 0.7373 mL | 3.6864 mL | 7.3727 mL | |
| 10 mM | 0.3686 mL | 1.8432 mL | 3.6864 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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