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    Z-VAD-FMK
    Z-VAD-FMK

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0028
    CAS #: 187389-52-2Purity ≥98%

    Description: Z-VAD-FMK (also known as Z-VAD(OMe)-FMK, and Z-Val-Ala-Asp(OMe)-FMK), a peptide compound, is a novel, potent cell-permeable and irreversible (covalent) inhibitor of pan-caspase. It is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1. Z-VAD-FMK inhibits apoptosis by blocking the activation of proCPP32 into its active form, rather than by preventing the proteolytic action of CPP32 directly. Z- VAD-FMK inhibits the formation of large kilobasepair fragments of DNA induced by diverse stimuli. Z-VAD-FMK had little or no effect on STS-induced necrotic cell death suggesting that the ICE-like protease activity was not involved in necrosis.

    References: Biochem J. 1996 Apr 1;315 ( Pt 1):21-4; Leukemia. 1997 Aug;11(8):1238-44.

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    Molecular Weight (MW)467.49
    FormulaC22H30FN3O7
    CAS No.187389-52-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 93 mg/mL (198 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: 24 mg/mL warming (51 mM)
    Other info

    Synonym: Z-VAD-FMK; Z VADFMK; ZVADFMK.

    Chemical Name: methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate

    InChi Key: MIFGOLAMNLSLGH-QOKNQOGYSA-N

    InChi Code: InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

    SMILES Code: O=C(OC)C[C@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)C(C)C)=O)C)=O)C(CF)=O


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    In VitroZ-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates.
    In VivoThe right ear swelling degree, weight differences and thickness between two ears in the 1.25 mML Z-VAD-FMK group were significantly lower than those of the negative control (NC). The levels of INF-γ and IL-2 in the ear skin lesions, the mean intensity of BrdU in T lymphocytes, and the percent of activation markers-positive T lymphocytes were all lower than those of NC.
    Animal model C57BL mice
    Formulation & Dosage1.25 mMl; Ear provocation
    ReferencesZhonghua Yi Xue Za Zhi. 2012 Jul 24;92(28):1992-6.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Z-VAD-FMK

     

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    Z-VAD-FMK


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