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    Z-VAD-FMK (Caspase Inhibitor VI)
    Z-VAD-FMK (Caspase Inhibitor VI)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0032
    CAS #: 161401-82-7Purity ≥98%

    Description: Z-VAD-FMK (Caspase Inhibitor VI; Z-VAD(OH)-FMK) is a novel, potent and irreversible pan caspase inhibitor. It does not require pretreatment with esterase for in vitro studies. Z-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes.

    References: Garcia-Calvo M, et al. J Biol Chem. 1998, 273(49), 32608-32613.


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    Molecular Weight (MW)453.46
    FormulaC21H28FN3O7
    CAS No.161401-82-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 90 mg/mL (198.47 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: N/A
    SMILESO=C(N[[email protected]](C(N[[email protected]@H](C)C(N[[email protected]@H](CC(O)=O)C(CF)=O)=O)=O)C(C)C)OCC1=CC=CC=C1
    Chemical NameZ-VAD(OH)-FMK; Z-VAD FMK L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-


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    In VitroZ-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes. As an irreversible general caspase inhibitor, it is useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I, this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 µl) solution of Caspase Inhibitor VI in DMSO is also available.
    In VivoN/A
    Animal modelN/A
    Formulation & DosageN/A
    ReferencesGarcia-Calvo M, et al. J Biol Chem. 1998, 273(49), 32608-32613.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Z-VAD-FMK (Caspase Inhibitor VI)

    Inhibition of caspases by tetrapeptide aldehydes. J Biol Chem. 1998 Dec 4;273(49):32608-13.
     

    Z-VAD-FMK (Caspase Inhibitor VI)

    Inhibition of caspases by CrmA. J Biol Chem.1998 Dec 4;273(49):32608-13.


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