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    Valsartan (CGP-48933)
    Valsartan (CGP-48933)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1777
    CAS #: 137862-53-4Purity ≥98%

    Description: Valsartan (formerly CGP-48933; CGP48933; Diovan, Prova, Tareg, Miten, Nisis, Vals, Walsarta), an approved antihypertensive drug, is a potent and selective angiotensin II receptor antagonist that is used for the treatment of high blood pressure and congestive heart failure. Valsartan is selective for the type I (AT1) angiotensin receptor. Valsartan dose-dependently inhibits the vasoconstriction induced by angiotensin II and lowers blood pressure in renin-dependent models of hypertension. 

    References: Expert Opin Investig Drugs. 1998 Nov;7(11):1915-25; Hypertension. 2010 Mar;55(3):715-21. 

    Related CAS #: 1111177-30-0 (Valsartan Ethyl Ester); 936623-90-4 [LCZ696 (Sacubitril/Valsartan)]; 137862-53-4 (Valsartan free); 149690-05-1 (sodium)  

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    • 香港大学
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    Molecular Weight (MW)435.52
    FormulaC24H29N5O3
    CAS No.137862-53-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 87 mg/mL (199.8 mM)
    Water:<1 mg/mL
    Ethanol: 87 mg/mL (199.8 mM)
    Other info

    Chemical Name: (S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}pentanamido)butanoic acid

    InChi Key: ACWBQPMHZXGDFX-QFIPXVFZSA-N

    InChi Code: InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1

    SMILES Code: CC(C)[[email protected]](N(CC1=CC=C(C2=CC=CC=C2C3=NNN=N3)C=C1)C(CCCC)=O)C(O)=O

    SynonymsCGP-48933; CGP 48933, CGP48933, Valsartan, Nisis, Prova, Tareg, Diovan, Miten, Vals, Walsartan


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    In Vitro

    In vitro activity: Valsartan dose-dependently inhibits the vasoconstriction induced by angiotensin II and lowers blood pressure in renin-dependent models of hypertension. Valsartan is at least as effective as ACE inhibitors, diuretics, beta-blockers and calcium antagonists.

    In VivoValsartan results in improved glucose tolerance, reduced fasting blood glucose levels, and reduced serum insulin levels in mice fed a Western diet. Valsartan treatment also blocks Western diet-induced increases in serum levels of the proinflammatory cytokines interferon-gamma and monocyte chemotactic protein 1. Valsartan enhances mitochondrial function and prevents Western diet-induced decreases in glucose-stimulated insulin secretion in the pancreatic islets of mice. Valsartan treatment blocks or attenuates Western diet-induced changes in expression of several key inflammatory signals: interleukin 12p40, interleukin 12p35, tumor necrosis factor-alpha, interferon-gamma, adiponectin, platelet 12-lipoxygenase, collagen 6, inducible NO synthase, and AT1R in isolated adipocytes. Valsartan significantly increases insulin-mediated 2-[3H]deoxy-d-glucose (2-[3H]DG) uptake into skeletal muscle and attenuates the increase in plasma glucose concentration after a glucose load and plasma concentrations of glucose and insulin. Valsartan treatment exaggerates the insulin-induced phosphorylation of IRS-1, the association of IRS-1 with the p85 regulatory subunit of phosphoinositide 3 kinase (PI 3-K), PI 3-K activity, and translocation of GLUT4 to the plasma membrane. Valsartan also reduces tumor necrosis factor-alpha (TNF-alpha) expression and superoxide production in skeletal muscle of KK-Ay mice.
    Animal modelMice
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    References

    Expert Opin Investig Drugs. 1998 Nov;7(11):1915-25; Hypertension. 2010 Mar;55(3):715-21. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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