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Sorafenib Tosylate (Bay 43-9006; Nexavar)

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InvivoChem Cat #: V1003

CAS #: 475207-59-1 Purity ≥98%

Description: Sorafenib Tosylate (BAY439006; BAY-439006; BAY549085; BAY-549085; Nexavar; SFN), the tosylate salt of Sorafenib which is an approved anticancer medication, is a potent multi-kinase inhibitor of Raf-1, B-Raf and VEGFR-2 with potential antineoplastic activity. It inhibits Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM in enzymatic assays, respectively. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer.

References: Cancer Res, 2004, 64(19), 7099-7109.

Related CAS#: 284461-73-0 (free base)

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Molecular Weight (MW)	637.03
Formula	C21H16ClF3N4O3.C7H8O3S
CAS No.	475207-59-1(tosylate);
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 127 mg/mL (199.4 mM)
	Water: <1 mg/mL (slightly soluble or insoluble)
	Ethanol: <1 mg/mL
Synonym	BAY 43-9006 tosylate; BAY549085; BAY-439-006; BAY 549085; BAY-439006 tosylate; BAY 439006; BAY439006 tosylate; BAY-549085; Nexavar; SFN.

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General	Oral administration of Sorafenib tosylate (~60 mg/kg) demonstrates broad spectrum, dose-dependent anti-tumor activity against a variety of human tumor xenograft models including MDA-MB-231, Colo-205, HT-29, DLD-1, NCI-H460, and A549, with no evidence of toxicity.
Animal model	Female NCr-nu/nu mice implanted s.c. with MDA-MB-231, Colo-205, HT-29, H460, or A549 cells
Formulation	Cremophor EL/ethanol (1:1) as 4-fold (4 × stock solution), and diluted to 1 × with w
Dosages	60 mg/kg
Administration	Administered orally once a day
Reference	[1] Wilhelm SM, et al. Cancer Res, 2004, 64(19), 7099-7109.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Purity ≥98%
COA
MSDS

Sorafenib Tosylate

The number of nuclei breaking the internal limiting membrane (ILM). A: Controlled group; B: ROP group; C: Vehicle-treated ROP group; D: Low doses sorafenib-treated ROP group; E: Middle doses sorafenib-treated ROP group; F: High dose sorafenib-treated ROP group.

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