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    Scopolamine HBr (Hyoscine)
    Scopolamine HBr (Hyoscine)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0034
    CAS #: 114-49-8Purity ≥98%

    Description: Scopolamine HBr, also known as Hyoscine, is the hydrobromide salt of scopolamine which is a competitive and non-selective antagonist of muscarinic acetylcholine receptor with an IC50 of 55.3 nM. Scopolamine is an approved medication used to treat motion sickness and postoperative nausea and vomiting. It is also occasionally used before surgery to decrease saliva. When used by injection effects begin after about 20 minutes and last for up to 8 hours. It may also be used by mouth and as a skin patch.

    References: Pharm Res. 1989 Jun;6(6):481-5; Int J Nanomedicine. 2011;6:897-904.


    Publications Citing Use of InvivoChem ScopolamineChem Biodivers. 2021 Sep 12. doi: 10.1002/cbdv.202100341

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    Molecular Weight (MW)384.26 
    FormulaC17H21NO4.HBr 
    CAS No.114-49-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 76 mg/mL (197.8 mM) 
    Water: 76 mg/mL (197.8 mM) 
    Ethanol: <1 mg/mL
    Solubility (In vivo)N/A
    SynonymsScopolamine HBr, (-)-Scopolamine hydrobromide, Scoburen; Hyoscine


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    In Vitro

    In vitro activity: Scopolamine (USAN), also known as levo-duboisine and hyoscine, sold as Scopoderm, is a tropane alkaloid drug with muscarinic antagonist effects. It is among the secondary metabolites of plants from Solanaceae (nightshade) family of plants, such as henbane, jimson weed (Datura), angel's trumpets (Brugmansia), and corkwood (Duboisia). Scopolamine exerts its effects by acting as a competitive antagonist at muscarinic acetylcholine receptors, specifically M1 receptors; it is thus classified as an anticholinergic, antimuscarinic drug.

    In VivoN/A
    Animal modelN/A
    Formulation & DosageN/A
    ReferencesN/A


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Scopolamine HBr




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