Propafenone HCl (SA-79)

Alias:
Cat No.:V1664 Purity: ≥98%
Propafenone HCl(formerly SA-79; SA79;Rytmonorm; Pronon; Arythmol; Baxarytmon; Cuxafenon; Fenoprain),the hydrochloride salt ofPropafenone, is an approved class 1C anti-arrhythmic drug.
Propafenone HCl (SA-79) Chemical Structure CAS No.: 34183-22-7
Product category: Sodium Channel
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
500mg
1g
2g
5g
10g
Other Sizes

Other Forms of Propafenone HCl (SA-79):

  • (S)-Propafenone
  • Propafenone (SA-79)
  • Propafenone D7 hydrochloride
  • Propafenone-d5 hydrochloride (propafenone d5 hydrochloride)
  • Propafenone-d5 Ethyl hydrochloride (propafenone d5 hydrochloride (Ethyl))
  • Propafenone-(phenyl-dd5) (hydrochloride)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Propafenone HCl (formerly SA-79; SA79; Rytmonorm; Pronon; Arythmol; Baxarytmon; Cuxafenon; Fenoprain), the hydrochloride salt of Propafenone, is an approved class 1C anti-arrhythmic drug. It acts as a sodium channel protein inhibitor, which has been used to treat illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

Biological Activity I Assay Protocols (From Reference)
ln Vivo
A traditional antiarrhythmic medication called propafenone (SA-79) hydrochloride is used to treat diseases like atrial and ventricular arrhythmias, which are characterized by fast heartbeats. Based on a revised classification system for rhinitis, the Allergic Rhinitis Affecting (ARIA) management guidelines prescribe intranasal antihistamines for the first-line care of intermittent intermittent, moderate/severe intermittent, and intermittent persistent rhinitis. Reduced cell excitability is the outcome of propafenone hydrochloride's disruption of sodium ion influx into cardiomyocytes. In comparison to Class Ia or Ib, propafenone hydrochloride is more selective for cells and has a higher rate, but it also blocks normal cells more thoroughly. Propafenone hydrochloride's additional action as a beta-preteraergic blocker, which results in bradycardia and arrest spasm, makes it an obvious classic Class Ic antiarrhythmic medication [1].
References
[1]. http://en.wikipedia.org/wiki/Propafenone
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C21H27NO3.HCL
Molecular Weight
377.9
CAS #
34183-22-7
SMILES
Cl[H].O(C1=C([H])C([H])=C([H])C([H])=C1C(C([H])([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)C([H])([H])C([H])(C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[H])O[H]
InChi Key
XWIHRGFIPXWGEF-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
Chemical Name
1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
Synonyms

Propafenone HCl; Rytmonorm; Pronon; Arythmol; Baxarytmon; Cuxafenon; Fenoprain;

Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO:69 mg/mL (182.6 mM)
Water:<1 mg/mL
Ethanol:<1 mg/mL
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.6462 mL 13.2310 mL 26.4620 mL
5 mM 0.5292 mL 2.6462 mL 5.2924 mL
10 mM 0.2646 mL 1.3231 mL 2.6462 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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