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Purity: ≥98%
Propafenone HCl (formerly SA-79; SA79; Rytmonorm; Pronon; Arythmol; Baxarytmon; Cuxafenon; Fenoprain), the hydrochloride salt of Propafenone, is an approved class 1C anti-arrhythmic drug. It acts as a sodium channel protein inhibitor, which has been used to treat illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
| ln Vivo |
A traditional antiarrhythmic medication called propafenone (SA-79) hydrochloride is used to treat diseases like atrial and ventricular arrhythmias, which are characterized by fast heartbeats. Based on a revised classification system for rhinitis, the Allergic Rhinitis Affecting (ARIA) management guidelines prescribe intranasal antihistamines for the first-line care of intermittent intermittent, moderate/severe intermittent, and intermittent persistent rhinitis. Reduced cell excitability is the outcome of propafenone hydrochloride's disruption of sodium ion influx into cardiomyocytes. In comparison to Class Ia or Ib, propafenone hydrochloride is more selective for cells and has a higher rate, but it also blocks normal cells more thoroughly. Propafenone hydrochloride's additional action as a beta-preteraergic blocker, which results in bradycardia and arrest spasm, makes it an obvious classic Class Ic antiarrhythmic medication [1].
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| References | |
| Additional Infomation |
Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).
Propafenone Hydrochloride is the hydrochloride salt form of propafenone with class 1C antiarrhythmic effects. Propafenone hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby reducing sodium influx required for the initiation and conduction of impulses in Purkinje and myocardial cells. This agent produces a marked depression of phase 0 and prolonged effective refractory period in the atrio-ventricular nodal and His-Purkinje tissue, resulting in a profound decrease in excitability, conduction velocity and automaticity, thereby counteracting atrial and ventricular arrythmias. An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. See also: Propafenone (has active moiety). |
| Molecular Formula |
C21H27NO3.HCL
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| Molecular Weight |
377.9
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| Exact Mass |
377.175
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| CAS # |
34183-22-7
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| Related CAS # |
(S)-Propafenone;107381-32-8;Propafenone;54063-53-5;Propafenone-d7 hydrochloride;1219799-06-0;Propafenone-d5 hydrochloride;1346605-05-7;Propafenone-d5 Ethyl hydrochloride;1398066-02-8;Propafenone-(phenyl-dd5) (hydrochloride);93909-48-9
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| PubChem CID |
36708
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| Appearance |
White to off-white solid powder
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| Boiling Point |
519.6ºC at 760 mmHg
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| Melting Point |
165-1670C
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| Flash Point |
268ºC
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| LogP |
4.434
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
26
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| Complexity |
368
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
XWIHRGFIPXWGEF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
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| Chemical Name |
1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.62 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.62 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6462 mL | 13.2310 mL | 26.4620 mL | |
| 5 mM | 0.5292 mL | 2.6462 mL | 5.2924 mL | |
| 10 mM | 0.2646 mL | 1.3231 mL | 2.6462 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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