| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| Other Sizes |
| ln Vivo |
AAA (10 mg/kg; orally; dissolved in water; once daily for 12 days) alleviated and reversed the development of angiotensin II-dependent malignant hypertension in Cyp1a1-Ren-2 transgenic rats, reduced associated kidney and heart damage, and inhibited elevated renal angiotensin II levels and plasma angiotensin-converting enzyme (ACE) activity [1]. AAA (10 mg/kg; orally; dissolved in water; once daily for 3 days) rapidly restored impaired renal hemodynamics and vascular reactivity in Cyp1a1-Ren-2 transgenic rats diagnosed with malignant hypertension [1].
|
|---|---|
| Animal Protocol |
Animal/Disease Models:Cyp1a1-Ren-2 transgenic mice (male; 0.3% indole-3-methanol diet-induced model of malignant hypertension)[1]
Doses: 10 mg/kg/day Route of Administration: Oral; once daily; 12 days Experimental Results: Systolic blood pressure decreased to 161 ± 3 mmHg (compared to 199 ± 3 mmHg in untreated I3C-induced rats). Reduced proteinuria, glomerular sclerosis index and cardiac hypertrophy. Reduced renal angiotensin II levels from 405 ± 14 fmol/g to 72 ± 6 fmol/g. Prevented weight loss, kyphosis, piloerection and polydipsia associated with untreated malignant hypertension. |
| References |
| Molecular Formula |
C24H39NNA2O6
|
|---|---|
| Molecular Weight |
483.55
|
| Related CAS # |
(Rac)-AAA; 3055022-23-3
|
| Appearance |
White to off-white solid
|
| SMILES |
O=C([C@@H](NC(CCCC/C=C\CCCCCCC/C=C\CCCCO)=O)CC(O[Na])=O)O[Na]
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). 本产品在运输和储存过程中需避光（避免光照）。 (2). 请将本产品存放在密封且受保护的环境中（例如氮气下），避免暴露在潮湿环境中。 |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~206.80 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 1 mg/mL (2.07 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), Clear solution; Need ultrasonic and warming.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0680 mL | 10.3402 mL | 20.6804 mL | |
| 5 mM | 0.4136 mL | 2.0680 mL | 4.1361 mL | |
| 10 mM | 0.2068 mL | 1.0340 mL | 2.0680 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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