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Prednisolone

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InvivoChem Cat #: V1698

CAS #: 50-24-8Purity ≥98%

Description: Prednisolone (AKOS-016010152; AK-115681; Predsol; Pediapred) is an approved medication acting as a potent and synthetic glucocorticoid with anti-inflammatory and immunomodulatory properties. Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats.

References: Proc Soc Exp Biol Med. 1994 Mar;205(3):220-9; J Clin Invest. 1993 Sep;92(3):1534-42.

Related CAS #: 50-24-8 (free) 52-21-1 (acetate) 125-02-0 (Na+ phosphate)

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Molecular Weight (MW)	360.44
Formula	C21H28O5
CAS No.	50-24-8
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 72 mg/mL (199.7 mM)
	Water:<1 mg/mL
	Ethanol: 10 mg/mL (27.7 mM)
Other info	Chemical Name: (8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one InChi Key: OIGNJSKKLXVSLS-VWUMJDOOSA-N InChi Code: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 SMILES Code: O=C1C=C[[email protected]]2(C)[[email protected]@]3([H])[[email protected]@H](O)C[[email protected]]4(C)[[email protected]](C(CO)=O)(O)CC[[email protected]@]4([H])[[email protected]]3([H])CCC2=C1
Synonyms	AKOS016010152; AK115681; AKOS 016010152; AK 115681; AKOS-016010152; AK-115681; sodium phosphate Predsol; Pediapred

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In Vitro	In vitro activity: Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats. Prednisolone's anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM) expression. Prednisolone (0.75 mg/kg) reduces macrophages (-59%, -57%), CD4(+) T-cells (-50%, -60%), CD8(+) T-cells (-58%, -48%), and eosinophils (-36%, -25%) in quadriceps and soleus muscles, respectively. Prednisolone-treated mice also exhibits decreased vascular P-selectin (-82%) and ICAM-1 (-52%) expression and fewer L-selectin (-79%) and ICAM-1 (-57%) expressing mononuclear cells in quadriceps. Prednisolone reduces sarcolemmal damage and degeneration as well in Dystrophin-deficient, mdx mice.
In Vivo	Prednisolone (5 mg/kg) causes alterations in diaphragmatic contractile properties and histological changes without fiber atrophy in rats. Prednisolone results in an increased number of diaphragmatic bundles in rats. Prednisolone induces a significant decline of PL-pO2, while CoBF, CMs, CAPs, and ABRs revealed no change in guinea pigs
Animal model	rats
Formulation & Dosage	5 mg/kg
References	Proc Soc Exp Biol Med. 1994 Mar;205(3):220-9; J Clin Invest. 1993 Sep;92(3):1534-42.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Purity ≥98%
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