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    Phenylephrine HCl
    Phenylephrine HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1130
    CAS #: 61-76-7 Purity ≥98%

    Description: Phenylephrine HCl (Metaoxedrine chloride; NCIc-55641; NCI c55641; Neosympatol; Oftalfrine; Mezaton; Neo Synephrine; Neo-Synephrine), the hydrochloride salt of Phenylephrine, is a potent and selective α1-adrenergic receptor agonist that is primarily used as a decongestant. It is used as a mydriatic, nasal decongestant, and cardiotonic agent. 

    References: J Biol Chem. 1994 Dec 30;269(52):32848-57; Am J Physiol. 1992 Mar;262(3 Pt 2):H754-62.

    Related CAS#: 59-42-7 (free base);  17119-15-2 (3-Hydroxymandelic Acid, a metabolite of Phenylephrine); 154-86-9 (DL-Phenylephrine HCl); 614-03-9 (L-Phenylephrine)

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    Molecular Weight (MW)203.67 
    FormulaC9H13NO2.HCl 
    CAS No.61-76-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 41 mg/mL (201.3 mM) 
    Water: N/A
    Ethanol: 41 mg/mL (201.3 mM) 
    Other infoChemical Name: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride
    InChi Key: OCYSGIYOVXAGKQ-FVGYRXGTSA-N
    InChi Code: InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
    SMILES Code: CNCC(C1=CC(=CC=C1)O)O.Cl
    SynonymsNCI-c55641; Phenylephrine Hydrochloride; Phenylephrine HCl; Metaoxedrine chloride; NCIc55641; NCI c55641; Neosympatol; Oftalfrine; Mezaton; Neo Synephrine; Neo-Synephrine; Neosynephrine ;Phenylephrine; Phenylephrine Hydrochloride; Phenylephrine Tannate;


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    In Vitro

    In vitro activity: Phenylephrine causes a rapid translocation of PKC-epsilon (EC50 = 0.9 mM) but the proportion lost from the soluble fraction is less than with ET-1. Phenylephrine at pCa 7 causes a dose-dependent increase in contractile force of the hyperpermeable cells, which is reversible on addition of phentolamine. Phenylephrine also protects cardiomyocytes against subsequent 24 h treatment with hypoxia and serum deprivation. Phenylephrine prevents the down-regulation of Bcl-2 and Bcl-X mRNA/protein and induces hypertrophic growth. Phenylephrine-mediated protection is abrogated by the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin and is mimicked by the caspase-9 peptidic inhibitor LEHD-fmk. Phenylephrine stimulates phosphoinositide (PI) hydrolysis, cell growth, and expression of several genes [e.g., atrial natriuretic factor (ANF)] often associated with cardiac hypertrophy. Phenylephrine markedly potentiates HGF-induced hepatocyte DNA synthesis and proliferation. Phenylephrine (10 mM) reversibly increases I(Ca,L) (51.3%; n = 40) and shifted peak I(Ca,L) activation voltage by -10 mV. Phenylephrine also increases local, subsarcolemmal SR Ca2+ release via IP3-dependent signaling. Phenylephrin-induced NOi release requires stimulation of both PI-3K/Akt and IP3-dependent Ca2+ signaling. Phenylephrine-induced NOi release is inhibited by each of 1 mM prazocin, 10 mM L-NIO, 10 mM W-7, 10 mM LY294002, 2 mM H-89, 10 mM ryanodine, 5 mM thapsigargin, 2 mM 2-APB or 10 mM xestospongin C.

    In VivoPerfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema.
    Animal modelRats
    Formulation & DosageA total of 170 male Wistar rats are randomLy allocated into 17 groups (n=10) using random number tables. Short-term (40 minutes) mechanical ventilation with high tidal volume is performed to induce lung injury, impair active Na+ transport and lung liquid clearance in the rats. Unventilated rats serves as controls. To demonstrate the effect of phenylephrine on alveolar fluid clearance, phenylephrine at different concentrations (10, 1, 0.1, 0.01, and 0.001 μM) is injected into the alveolar space of the HVT ventilated rats.
    ReferencesJ Biol Chem. 1994 Dec 30;269(52):32848-57; Am J Physiol. 1992 Mar;262(3 Pt 2):H754-62; Chin Med Sci J. 2013 Mar;28(1):1-6.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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