Size | Price | Stock | Qty |
---|---|---|---|
500mg |
|
||
Other Sizes |
|
ln Vitro |
(R)-(-)-Phenylephrine has pKi values of 5.86, 4.87, and 4.70 for α1D, α1B, and α1A receptors, respectively, making it a selective α1-adrenergic receptor agonist [1][2]. This myocardium may be the target of treatment for myocardial fibrosis because phenylephrine stimulates cardiac fibroblasts, indicating that Ca (2+)/CaN/NFAT does not drive phenylephrine-induced cardiac fibroblast proliferation [3].
|
---|---|
ln Vivo |
Both p38-MAPK isoforms were rapidly activated by 12 times (maximum at 10 min) upon perfusion of the heart with 100 μM phenylephrine. α1-Syntropin is responsive to anesthetics that enhance the heart's contractility, including phenylephrine. Newborn ventricular myocytes' SAPKs and JNKs are activated by phenylephrine[4]. Phenylephrine has the ability to speed up the absorption of pulmonary edema and raise the alveolar fluid clearance rate of air volume ventilation transport [5].
|
References |
[1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.
[2]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. [3]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13. [4]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65. [5]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6 |
Molecular Formula |
C9H13NO2
|
---|---|
Molecular Weight |
167.2
|
Exact Mass |
167.0946
|
CAS # |
59-42-7
|
Related CAS # |
Phenylephrine hydrochloride;61-76-7
|
SMILES |
O([H])[C@]([H])(C1C([H])=C([H])C([H])=C(C=1[H])O[H])C([H])([H])N([H])C([H])([H])[H]
|
Synonyms |
Metasynephrine; Metaoxedrin; Phenylephrine
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
DMSO : ~50 mg/mL (~299.03 mM)
H2O : ~5 mg/mL (~29.90 mM) |
---|---|
Solubility (In Vivo) |
Solubility in Formulation 1: 10 mg/mL (59.81 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with heating and sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.9809 mL | 29.9043 mL | 59.8086 mL | |
5 mM | 1.1962 mL | 5.9809 mL | 11.9617 mL | |
10 mM | 0.5981 mL | 2.9904 mL | 5.9809 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.