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    Omeprazole (H 16868)
    Omeprazole (H 16868)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1633
    CAS #: 73590-58-6Purity ≥98%

    Description: Omeprazole (H-16868; H16868; trade names: Prilosec, Zegerid), approved by the FDA, is available as a prescription and over-the-counter (OTC) drug used as a treatment for frequent heartburn. Omeprazole is a proton pump inhibitor with an IC50 of 5.8 μM, and has been approved for use in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux, and Zollinger–Ellison syndrome. Omeprazole. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid. 

    References: J Biol Chem. 1997 May 9;272(19):12705-13; Am J Physiol. 1994 Apr;266(4 Pt 1):G745-58.

    Related CAS#:95510-70-6 (sodium); 119141-88-7 (S-isomer); 95510-71-7 (potassium); 73590-85-9 (Omeprazole metabolite Omeprazole sulfide; Ufiprazole; Omeprazole sulfide); 88546-55-8 (Omeprazole metabolite Omeprazole sulfone; Omeprazole sulfone; Omeprazole sulphone); 922731-01-9 (Omeprazole D3; H 16868 D3); 73590-58-6 (free form)

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    Molecular Weight (MW)345.42
    CAS No.73590-58-6  (free); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 69 mg/mL (199.8 mM)
    Water:<1 mg/mL
    Ethanol: 13 mg/mL (37.6 mM)
    Solubility (In vivo)2% DMSO+30% PEG 300+ddH2O: 5mg/mL  
    SynonymsOmeprazole, H 168-68, Losec, Prilosec, Zegerid, H 16868, H 168 68  

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    In Vitro

    In vitro activity: Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect.

    In VivoOmeprazole blocks H(+)-K(+)-ATPase, thus enhances degeneration and macrophage-mediated elimination of parietal cells and also causes an increase in preparietal cell production. Omeprazole temporarily changes the dynamic features of parietal cells in the rabbit to make them die early and grow fast.
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    ReferencesJ Biol Chem. 1997 May 9;272(19):12705-13; Am J Physiol. 1994 Apr;266(4 Pt 1):G745-58.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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