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    KN-92 Hydrochloride
    KN-92 Hydrochloride

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V2803
    CAS #: 1431698-47-3Purity ≥98%

    Description: KN-92 Hydrochloride, the hydrochloride salt of KN-92, is an inactive derivative of KN-93. KN-92 is intended to be used as a negative control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.

    References: World J Gastroenterol. 2007;13(9):1445-8; Cancer Biol Ther. 2010;9(3):224-35; 2006;345(4):1606-10.

    Related CAS #: 176708-42-2 (free base)  1431698-47-3 (HCl)  1135280-28-2 (phosphate)

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    Molecular Weight (MW)493.45
    FormulaC24H26Cl2N2O3S
    CAS No.1431698-47-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO:  ~25mg/mL                
    Water: N/A
    Ethanol: N/A
    Chemical Name

    (E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-4-methoxybenzenesulfonamide phosphate

    Synonyms

    KN-92 HCl; KN-92; KN 92; KN92


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    In Vitro

    In vitro activity: KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.


    Cell Assay: KN-92 is an inactive derivative of KN-93. It is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.

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    Formulation & Dosage
    References

    World J Gastroenterol. 2007 Mar 7;13(9):1445-8; Cancer Biol Ther. 2010 Feb;9(3):224-35. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    KN-92 Hydrochloride

    WST-8 assay showing the effect of KN-93 and KN-92 on the growth of LX-2 cells after incubation for 24 h (A) and at the indicated time (B).  World J Gastroenterol. 2007 Mar 7;13(9):1445-8.
     
     

    KN-92 Hydrochloride

    Effects of KN-93 (A) and KN-92 (B) on expression of p53 in LX-2 cells. World J Gastroenterol. 2007 Mar 7;13(9):1445-8.
     

    KN-92 Hydrochloride

    Effects of KN-93 (A) and KN-92 (B) on expression of p21 in LX-2 cells. World J Gastroenterol. 2007 Mar 7;13(9):1445-8.


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