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    Heparin sodium
    Heparin sodium

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1850
    CAS #: 9041-08-1Purity ≥98%

    Description: Heparin sodium (150,160,170,180unit/mg),  a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is widely used as an anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin and the structurally related heparan sulfate are complex linear polymers comprised of a mixture of chains of different length, having variable sequences.

    References: Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.

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    Molecular Weight (MW)6000-20000  
    Formula(C12H16NS2Na3)20 
    CAS No.9041-08-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL
    Water: < 1 mg/mL
    Ethanol: <1 mg/mL
    SMILESC([[email protected]@H]1C([[email protected]@H](C(C(O1)O)NS(=O)(=O)[O-])O)O[[email protected]]2C([[email protected]](C(C(O2)C(=O)[O-])O)O)OS(=O)(=O)[O-])OS(=O)(=O)[O-]
    SynonymsM118; M-118; M 118; Adomiparin; Bemiparin; Certoparin; Dalteparin; Eparina; Fraxiparin; Nadroparine; Parvoparin; Thromboliquine


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    In Vitro

    In vitro activity: Heparin is widely used as an anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin and the structurally related heparan sulfate are complex linear polymers comprised of a mixture of chains of different length, having variable sequences. Heparin interactes most tightly with peptides containing a complementary binding site of high positive charge density. Heparin and heparan sulfate predominantly exhibit linear helical secondary structures with sulfo and carboxyl groups displayed at defined intervals and in defined orientations along the polysaccharide backbone. Heparin resembles DNA as both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin binds to AT III and thrombin in a ternary complex, increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization. 

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    References

    Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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