Size | Price | Stock | Qty |
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5mg |
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10mg |
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Other Sizes |
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ln Vivo |
In solution 5-HT, fluvoxamine (DU-23000) efficiently suppresses brain synaptosomes and synaptosomes. It is believed that effects on 5-HT foods account for the solitary antagonistic impact of fluvoxamine on the reserpine-induced reduction of the convulsive threshold by pentamethylenetetrazolium. When the active reserpine-like compound was administered after taking a rapid voxamine preparation, no stimulating impact was observed among the impurities, in contrast to the activity of desmethylpyridine and pyrimidine [1]. It seems that combat-related PTSD symptoms can be alleviated with fluvoxamine (DU-23000), but not depressed symptoms. Our study's outcomes were a high moisture fraction and no restrictions on moisture grouping. It is necessary to conduct controlled research on fluvoxamine in the treatment of PTSD [2]. When food is supplied concurrently with ethanol, fluvoxamine (DU-23000) reduces ethanol self-drugs less effectively than when ethanol is provided alone (ED50: 4.0 (2.7-5.9) versus 5.1 (4.3-6.0)). When the spindle had access to food, the effects on food were comparable. The effectiveness of fluvoxamine in decreasing behavior maintained by ethanol is dependent upon whether ethanol is employed in conjunction with concurrently planned food reinforcement or not [3].
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References |
[1]. Escalona, R., et al., Fluvoxamine treatment in veterans with combat-related post-traumatic stress disorder. Depress Anxiety, 2002. 15(1): p. 29-33.
[2]. Ginsburg, B.C., J.W. Pinkston, and R.J. Lamb, The potency of fluvoxamine to reduce ethanol self-administration decreases with concurrent availability of food. Behav Pharmacol, 2012. 23(2): p. 134-42. [3]. Claassen, V., et al., Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br J Pharmacol, 1977. 60(4): p. 505-16. |
Molecular Formula |
C15H21N2O2F3
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Molecular Weight |
318.33464
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CAS # |
54739-18-3
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Related CAS # |
Fluvoxamine maleate;61718-82-9
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SMILES |
FC(C1=CC=C(/C(CCCCOC)=N/OCCN)C=C1)(F)F
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~160 mg/mL (~502.62 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.53 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.08 mg/mL (6.53 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (6.53 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.1414 mL | 15.7070 mL | 31.4139 mL | |
5 mM | 0.6283 mL | 3.1414 mL | 6.2828 mL | |
10 mM | 0.3141 mL | 1.5707 mL | 3.1414 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.