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      Flavoxate HCl (Rec-7-0040; DW61)
      Flavoxate HCl (Rec-7-0040; DW61)

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V1197
      CAS #: 3717-88-2Purity ≥98%

      Description: Flavoxate HCl (Rec-7-0040; DW-61; NSC-114649; Rec 7-0040; Rec7-0040; DW61; NSC114649), the hydrochloride salt of Flavoxate which is a flavanoid, is a muscarinic AChR antagonist with an IC50 of 12.2 μM.  

      References: Int J Urol. 1996 May;3(3):218-27; Brain Res. 1996 Jul 15;727(1-2):91-8.

      Related CAS NO. 15301-69-6 (free base)

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      Molecular Weight (MW)427.92 
      FormulaC24H25NO4.HCl 
      CAS No.3717-88-2 
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 3 mg/mL (7.0 mM) 
      Water: 10 mg/mL (23.4 mM) 
      Ethanol: <1 mg/mL
      Solubility (In vivo)30% Propylene glycol, 5% Tween 80, 65% D5W:  30 mg/mL
      SynonymsRec-7-0040; DW-61; NSC-114649; Rec 7-0040; DW 61; NSC 114649; Rec7-0040; DW61; NSC114649 


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      In Vitro

      In vitro activity: Flavoxate displaces [3H]nitrendipine on the Ca2+ channels binding sites with IC50 of 254 μM. Flavoxate (>10 μM) suppresses carbachol-induced contractions in isolated rat detrusor strips with pD value of 4.55. Flavoxate (>10 μM) suppresses Ca2+-induced contractions in isolated rat detrusor strips with pIC50 value of 4.92. Flavoxate (0.01 μM −10 μM) inhibits CAMP formation in a concentration-dependent manner in membranes from the rat striatum and cerebral cortex, an action which is completely abolished by pretreating the membranes with pertussis toxin (PTX). Flavoxate causes a concentration-dependent reduction of the K+-induced contraction of human urinary bladder. Flavoxate inhibits the peak amplitude of voltage-dependent nifedipine-sensitive inward Ba2+ currents in a voltage- and concentration-dependent manner with Ki value of 10 μM in human detrusor myocytes.

      In VivoFlavoxate (10mg/kg) suppresses both the an initial, rapidly rising phasic contraction (phase 1) and the tonic contraction (phase 2) contractions to the same extent in rats. Flavoxate (10mg/kg) abolishes the bladder contractions without causing any change in the amplitude of the contractions in rats. Flavoxate (3 mg/kg) abolishes the efferent neural activity and the associated bladder contractions for about 10 minutes without changing the baseline vesical pressure in rats. ICV-injected (50 to 200 μg/rat) or IT-injected (100 to 200 μg/rat) Flavoxate abolishes rhythmic bladder contractions during and after injection for five to 15 minutes in a dose-dependent manner in rats. Flavoxate (3 mg/kg, i.v.) abolishes rhythmic bladder contractions and the maximal intervals of voiding contractions is 7.20 min. 
      Animal modelSprague-Dawley rats 
      Formulation & DosageDissolved in saline; 10 mg/kg; i.v. injection
      References

      Int J Urol. 1996 May;3(3):218-27; Brain Res. 1996 Jul 15;727(1-2):91-8. 

      These protocols are for reference only. InvivoChem does not independently validate these methods.

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