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Description: Flavoxate HCl (Rec-7-0040; DW-61; NSC-114649; Rec 7-0040; Rec7-0040; DW61; NSC114649), the hydrochloride salt of Flavoxate which is a flavanoid, is a muscarinic AChR antagonist with an IC50 of 12.2 μM.
References: Int J Urol. 1996 May;3(3):218-27; Brain Res. 1996 Jul 15;727(1-2):91-8.
Related CAS NO. 15301-69-6 (free base)
Product Catalog 2022
Guide to Product Handling
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Flavoxate displaces [3H]nitrendipine on the Ca2+ channels binding sites with IC50 of 254 μM. Flavoxate (>10 μM) suppresses carbachol-induced contractions in isolated rat detrusor strips with pD value of 4.55. Flavoxate (>10 μM) suppresses Ca2+-induced contractions in isolated rat detrusor strips with pIC50 value of 4.92. Flavoxate (0.01 μM −10 μM) inhibits CAMP formation in a concentration-dependent manner in membranes from the rat striatum and cerebral cortex, an action which is completely abolished by pretreating the membranes with pertussis toxin (PTX). Flavoxate causes a concentration-dependent reduction of the K+-induced contraction of human urinary bladder. Flavoxate inhibits the peak amplitude of voltage-dependent nifedipine-sensitive inward Ba2+ currents in a voltage- and concentration-dependent manner with Ki value of 10 μM in human detrusor myocytes.
Int J Urol. 1996 May;3(3):218-27; Brain Res. 1996 Jul 15;727(1-2):91-8.
Purity ≥98%
COA
MSDS