| Size | Price | Stock | Qty |
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| 10mg |
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Clorgyline is a novel and potent antidepressive agentand monoamine oxidase inhibitor
| References | |
|---|---|
| Additional Infomation |
Clorgyline is an aromatic ether, a 2,4-dichlorophenyl ether of 3-aminoprop-1-ol, wherein the nitrogen atom is replaced by a methyl group and a prop-1-yn-3-yl group. It is a monoamine oxidase inhibitor and was formerly used as an antidepressant. It has a dual role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and an antidepressant. It is a tertiary amine compound, a terminal alkyne compound, an aromatic ether, and a dichlorobenzene.
An antidepressant and monoamine oxidase inhibitor associated with Clorgyline. An antidepressant and monoamine oxidase inhibitor associated with Clorgyline. |
| Molecular Formula |
C13H15CL2NO
|
|---|---|
| Molecular Weight |
272.169
|
| Exact Mass |
271.053
|
| CAS # |
17780-72-2
|
| Related CAS # |
Clorgyline hydrochloride; 17780-75-5
|
| PubChem CID |
4380
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
1.196g/cm3
|
| Boiling Point |
361.3ºC at 760mmHg
|
| Flash Point |
172.3ºC
|
| Vapour Pressure |
2.1E-05mmHg at 25°C
|
| Index of Refraction |
1.546
|
| LogP |
3.327
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
17
|
| Complexity |
263
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CN(CCCOC1=C(C=C(C=C1)Cl)Cl)CC#C
|
| InChi Key |
BTFHLQRNAMSNLC-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
|
| Chemical Name |
3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine
|
| Synonyms |
Clorgyline M & B 9302 Clorgiline
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| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~367.4 mM; with ultrasonication)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.19 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6742 mL | 18.3709 mL | 36.7417 mL | |
| 5 mM | 0.7348 mL | 3.6742 mL | 7.3483 mL | |
| 10 mM | 0.3674 mL | 1.8371 mL | 3.6742 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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