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    Clopidogrel sulfate
    Clopidogrel sulfate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1301
    CAS #: 120202-66-6 Purity ≥98%

    Description: Clopidogrel sulfate (Plavix; Zyllt; Osvix; Plavitor, SR-25990C), the sulfate salt of Clopidogrel, is an orally bioavailable, thienopyridine class of antiplatelet agent acting as an irreversible inhibitor of ADP receptor (P2Y12). Clopidogrel is a prodrug that has to be activated by CYP2C19. It is approved as an antiplatelet and anticoagulant medication used to reduce the risk of heart disease and stroke in those at high risk. Clopidogrel works by irreversibly inhibiting a receptor called P2Y12, an adenosine diphosphate (ADP) chemoreceptor on platelet cell membranes. Clopidogrel acts by inhibiting the ADP receptor on platelet cell membranes. 

    References: Eur J Pharmacol. 2012 Nov 15;695(1-3):112-9; Basic Res Cardiol. 2011 May;106(3):485-94.

    Related CAS#: 120202-65-5 (HCl); 90055-48-4 (racemate); 120202-67-7 (HBr); 1147350-75-1 (2-Oxoclopidogrel); 120202-66-6 (bisulfate); 120202-65-5 (HCl); 744256-69-7 (besylate); 113665-84-2 (free base)

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    Molecular Weight (MW)419.9
    CAS No.120202-66-6(bisulfate); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 83 mg/mL (197.7 mM)
    Water: 78 mg/mL (185.7 mM)
    Ethanol: 46 mg/mL (109.5 mM)
    Other info
    Chemical Name: methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate sulfate
    InChi Code: InChI=1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)/t15-;/m0./s1
    SMILES Code: O=C(OC)[[email protected]](C1=CC=CC=C1Cl)N2CCC3=C(C=CS3)C2.O=S(O)(O)=O 
    SynonymsSR-25990C; Plavix; (S)-Clopidogrel; Clopidogrelum; Zyllt. Clopidogrel sulfate; Osvix; Plavitor, SR 25990C; SR-25990C; SR25990C; SR 25990.

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    In Vitro

    In vitro activity: Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5.

    In VivoClopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy.  
    Animal model Rats
    Formulation & Dosage 2mg and 10mg/kg
    ReferencesEur J Pharmacol. 2012 Nov 15;695(1-3):112-9; Basic Res Cardiol. 2011 May;106(3):485-94.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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