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      Batimastat (BB94)
      Batimastat (BB94)

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      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V0735
      CAS #: 130370-60-4Purity ≥98%

      Description: Batimastat (formerly known as BB-94), a synthetic hydroxamate analog and an anticancer drug developed by Laurie Hines of British Biotech, is a broad spectrum inhibitor of matrix metalloprotease (MMP) with potential antitumor activity. It inhibits MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. It also inhibits the activitity of other metalloproteases, such as ADAM17. It exhibits antineoplastic and antiangiogenic activity in various tumor models, including ovarian carcinoma xegnografts and human colon tumor.

      References: Int J Cancer. 1994 Aug 1;58(3):460-4; Cancer Res. 1994 Sep 1;54(17):4726-8.

      Related CAS #: 130464-84-5(sodium)   130370-60-4 (free base)       

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      Molecular Weight (MW)477.64
      FormulaC23H31N3O4S2
      CAS No.130370-60-4
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 96 mg/mL (201.0 mM)
      Water: <1 mg/mL
      Ethanol: <1 mg/mL
      Solubility (In vivo)30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
      SynonymsBB94; Batimastat; BB 94; BB-94.

      IUPAC/Chemical Name: (2S,3R)-N-Hydroxy-N'-[(2S)-1-methylamino-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide.

      InChi Key: XFILPEOLDIKJHX-QYZOEREBSA-N

      InChi Code: InChI=1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1

      SMILES Code: O=C(NO)[[email protected]@H](CSC1=CC=CS1)[[email protected]@H](CC(C)C)C(N[[email protected]@H](CC2=CC=CC=C2)C(NC)=O)=O


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      In Vitro

      In vitro activity: Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site.

      Kinase Assay: Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.

      Cell Assay: In vitro proliferation in the presence of batimastatwas assessed by the MTT absorbance assay. The effect of batimastat on the in vitro growth of C170HM2 and AP5LV in both serum-free and scrum-containing culture media was determined three times. Batimastat had no significant effect on the growth of either cell line.

      In VivoBatimastat can inhibit metastatic spread and growth of B16-BL6 murine melanoma. In an orthotopic colon tumor model in mice, timastat treatment results in inhibition of primary tumor growth (by 50%), local/regional spread(from 67% to 35%), and distant metastasis(from 30% to 10%). Batimastat reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures.
      Animal modelNude mice
      Formulation & DosageDissolved in PBS containing 0.01% Tween 2O; 30 mg/kg; i.p. injection
      References

      Int J Cancer. 1994 Aug 1;58(3):460-4; Cancer Res. 1994 Sep 1;54(17):4726-8; J Natl Cancer Inst. 1995 Feb 15;87(4):293-8.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

       

      Batimastat (BB-94)

      		 

      Batimastat (BB-94)

      		 

      Batimastat (BB-94)

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