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      Atropine sulfate monohydrate
      Atropine sulfate monohydrate

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V1173
      CAS #: 5908-99-6Purity ≥98%

      Description: Atropine sulfate monohydrate (Sulfatropinol; Tropintran; Atropette; Corbella), the sulfate salt and hydrated form of atropine, is a competitive and broad-spectrum antagonist of the muscarinic acetylcholine receptors. It has been approved for decreasing the production of saliva and secretions of the airway prior to surgery. 

      References: Vis Neurosci. 2000 Mar-Apr;17(2):165-76; Neurosci Lett. 2003 Jul 17;345(2):97-100.

      Related CAS #: 5908-99-6 (sulfate)   6415-90-3 (HBr)   51-55-8 (free base)   

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      Molecular Weight (MW)694.83 
      Formula2(C17H23NO3).H2O.H2SO4 
      CAS No.5908-99-6 
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 139 mg/mL (200 mM) 
      Water: 139 mg/mL (200 mM) 
      Ethanol: 139 mg/mL (200 mM) 
      Other info

      Chemical Name: (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate;sulfuric acid, hydrate

      InChi Key: PVGPXGKNDGTPTD-UHFFFAOYSA-N

      InChi Code: InChI=1S/C17H23NO3.H2O4S.H2O/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2

      SMILES Code: O=S(O)(O)=O.O=C(OC1CC(N2C)CCC2C1)C(C3=CC=CC=C3)CO.[H]O[H]

      Synonyms

      Atropine sulphate; Sulfatropinol; Tropintran; Atropette; Corbella; Atropine Sulfate; Atropine Sulfate hydrate


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      In Vitro

      In vitro activity: Atropine increases the release of the neurotransmitter dopamine into the superfusate in vitro at 100-500 mM and into the vitreous in vivo at 250 mg. Atropine induces spreading depression (SD) in the in vitro preparation. Atropine reduces the ERG b- and d-wave, leads to damped oscillations of RPE potentials, and reverses the ERG c-wave. Atropine suppresses myopia only at doses at which severe nonspecific side effects are observed in the retina.

      Kinase Assay: Atropine increases the release of the neurotransmitter dopamine into the superfusate in vitro at 100-500 mM and into the vitreous in vivo at 250 mg. Atropine induces spreading depression (SD) in the in vitro preparation. Atropine reduces the ERG b- and d-wave, leads to damped oscillations of RPE potentials, and reverses the ERG c-wave. Atropine suppresses myopia only at doses at which severe nonspecific side effects are observed in the retina.

      In VivoAtropine (1.0 mg/kg, i.p.), but not methylatropine (1.0 mg/kg, i.p.), prevents the enhancement of retention induced by both doses of the anticholinesterase when given immediately after training in mice. Atropine administration effectively prevents bradycardia and second-degree heart block but induces pulsus alternans and hypertension in dogs. Atropine has no effect on handling-induced acetylcholine output in the presence of 10 nM neostigmine, but causes greater and longer increases in the presence of 100 nM and 1000 nM neostigmine in rats. Atropine not only blocks the rapid eye movement (REM) sleep increases induced by CGS but it also tends to decrease REM sleep compared to atropine preceding saline in rats. Atropine decreases the time to exhaustion by 67% in intact rats and by 96.2% in adrenodemedullated (ADM) and also reduces the exercise-induced pituitary prolactin (PRL) release in both intact (50%) and ADM rats (90%).
      Animal modelMice
      Formulation & Dosage1.0 mg/kg, i.p.
      References

      Vis Neurosci. 2000 Mar-Apr;17(2):165-76; Neurosci Lett. 2003 Jul 17;345(2):97-100. 

      These protocols are for reference only. InvivoChem does not independently validate these methods.

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