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Purity: ≥98%
Amoxicillin (Amoxycillin and amox), a moderate-spectrum, bacteriolytic, orally bioactive β-lactam antibiotic of the penicillin class, is widely used to treat a number of bacterial infections, including bronchitis, pneumonia, and infections of the ear, nose, throat, skin, and urinary tract. Though it can be highly effective in treating bacterial infections, it also comes with a list of potential side effects. It inhibits bacterial cell wall biosynthesis by preventing peptidoglycan cross-linking. Shows bacteriocidal effects against gram-positive and gram-negative species in vivo. Amoxicillin is often times combined with Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-Lactamase inhibitor.
| ln Vitro |
In a dose-dependent manner, amoxicillin (Amoxycillin) (1-100 µM; 24 hours; L. acidophilus) reduces living cells and increases the degree of cell wall rupture[1].
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| ln Vivo |
Rat survival rates are increased when rats are given amoxicillin (Amoxycillin) at a dose of 7 mg/kg (i.h.; female ICR/Swiss mice) and strain numbers are inhibited[2].
Swiss albino mice given amoxicillin (also known as amoxycillin) (1.6–9.5 mg/kg; p.o.; daily, for 7 or 14 days) are protected against chlamydia trachomatis infection[3]. |
| Animal Protocol |
Animal Model: Female ICR/Swiss mice[2]
Dosage: 7 mg/kg Administration: Subcutaneous injection: every eight hours for a full day Result: exhibited a dose-dependent inhibition on the number of bacteria. |
| References |
| Molecular Formula |
C16H19N3O5S
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| Molecular Weight |
365.4
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| Exact Mass |
365.10454
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| Elemental Analysis |
C, 52.59; H, 5.24; N, 11.50; O, 21.89; S, 8.78
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| CAS # |
26787-78-0
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| Related CAS # |
Amoxicillin sodium;34642-77-8;Amoxicillin trihydrate;61336-70-7;Amoxicillin-d4;2673270-36-3;Amoxicillin trihydrate mixture with potassium clavulanate (4:1);Amoxicillin-13C6;Amoxicillin arginine;59261-05-1
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| Appearance |
White to off-white solid powder.
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| SMILES |
CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
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| InChi Key |
LSQZJLSUYDQPKJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)
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| Chemical Name |
(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
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| Synonyms |
Amoxicilline Amoxicillin anhydrous Clamoxyl Amopenixin AmoxAmoxycillin; Amoxicilline; Amoxicillin anhydrous; Clamoxyl; Amopenixin; Amox
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 73 ~83.33 mg/mL (228.05~199.78 mM)
H2O : ~2 mg/mL (~5.47 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.69 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.69 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (5.69 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.08 mg/mL (5.69 mM) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7367 mL | 13.6836 mL | 27.3673 mL | |
| 5 mM | 0.5473 mL | 2.7367 mL | 5.4735 mL | |
| 10 mM | 0.2737 mL | 1.3684 mL | 2.7367 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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