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Purity: ≥98%
Acetylcholine Chloride (ACh chloride; Ovisot; TL-1505; TL-1505) is an organic chemical and a common neurotransmitter found in the central and peripheral nerve system that functions in the brain and body of many types of animals, including humans, as a neurotransmitter—a chemical released by nerve cells to send signals to other cells. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Parts in the body that use or are affected by acetylcholine are referred to as cholinergic. Substances that interfere with acetylcholine activity are called anticholinergics. is
| ln Vitro |
While sweat gland epithelial cell fluorescence values and intracellular free calcium are decreased in calcium-free myocardium, cardiac choline chloride (ACh chloride; 10 μM) calcium channel, fluorescence values, and intracellular free calcium are significantly increased in hypercalcium myocardium [3].
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| ln Vivo |
In mice, acetylcholine chloride (ACh chloride; SC; 20 mg/kg; single dose) significantly increases cholinergic stimulation and morbidity [4].
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| Animal Protocol |
Animal/Disease Models: Male and female inbred albino mice weighing 18-22 grams (sepsis) [4]
Doses: 20 mg/kg Route of Administration: subcutaneous injection; single dose Experimental Results: Dramatically diminished intraperitoneal (ip) injection of 2×109 large intestine Mortality of mice with sepsis caused by bacilli and blood levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6. |
| References |
[1]. Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3(5): 413-420.
[2]. A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9. [3]. Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41. [4]. P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2. [5]. Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357. |
| Molecular Formula |
C7H16NO2.CL
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| Molecular Weight |
181.66
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| CAS # |
60-31-1
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| Related CAS # |
Acetylcholine iodide;2260-50-6;Acetylcholine bromide;66-23-9;Acetylcholine-d4 chloride;344298-94-8;Acetylcholine-d9 chloride;344298-95-9
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| SMILES |
[Cl-].O(C(C([H])([H])[H])=O)C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.5048 mL | 27.5239 mL | 55.0479 mL | |
| 5 mM | 1.1010 mL | 5.5048 mL | 11.0096 mL | |
| 10 mM | 0.5505 mL | 2.7524 mL | 5.5048 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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