| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 10g |
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| 25g |
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Purity: ≥98%
Gamma-Aminobutyric Acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. γ-Aminobutyric acid (GABA) functions primarily as an inhibitory neurotransmitter in the mature central nervous system. The addition of GABA into the cell culture medium promoted the proliferation of GABRP-expressing PDAC cells, but not GABRP-negative cells, and GABAA receptor antagonists inhibited this growth-promoting effect by GABA.
| ln Vitro |
γ-aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), causes an inward current in ventricular zone (VZ) cells, and inhibits DNA synthesis; the half-maximum response concentration is 5 μM[3]. The chemotropic signal involves G-protein activation, and cortical plate (cp) neurons express glutamic acid decarboxylase (GAD). γ-Aminobutyric acid (1–5 μM; 18 h) stimulates motility and stops cp cell migration. Growth is restricted and cell cycle arrest occurs in S phase due to the activation of GABA A receptors by γ-aminobutyric acid[5].
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| ln Vivo |
Mice's sleep can be improved by γ-aminobutyric acid (33.95, 102.25, 306.75 mg/kg; po; single dose)[6]. ?After exposure to Di(2-ethylhexyl) phthalate (DEHP), rats' anxiety levels are reduced and their food utilization rate is restored when given γ-aminobutyric acid (1, 2, 4 mg/kg/d; po; 30 d)[7].
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| Cell Assay |
Cell Migration Assay [4]
Cell Types: Cortical plate (cp) neurons Tested Concentrations: 1-5 μM Incubation Duration: 18 hrs (hours) Experimental Results: Promoted motility via G-protein activation and arrested attractant-induced migration via GABAA receptor-mediated depolarization. |
| Animal Protocol |
Animal/Disease Models: Pathogens free (SPF) Bagg's albino (Balb/c) mice (18– 20 g, 8 weeks old)[6]
Doses: 33.95, 102.25, 306.75 mg/kg Route of Administration: po (oral gavage); single dose; 20 mL/kg administration; measured in an hour Experimental Results: Prolonged the sleep duration, increased sleep rate, and shorten the sleep latency more effectively. Animal/Disease Models: SD (Sprague-Dawley) rat induced by DEHP (500 mg/kg)[7] Doses: 1, 2, 4 mg/kg Route of Administration: po (oral gavage); combined administration; for 30 days Experimental Results: decreased the levels of nitric oxide and nitric oxide synthase in rats treated with DEHP. |
| References |
[1]. Chen S, et al. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 2.
[2]. Okada R, et al. Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe. J Comp Neurol. 2009 May 1;514(1):74-91. |
| Molecular Formula |
C4H9NO2
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| Molecular Weight |
103.12
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| CAS # |
56-12-2
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| Related CAS # |
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| SMILES |
O=C(O)CCCN
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| Synonyms |
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (969.74 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.6974 mL | 48.4872 mL | 96.9744 mL | |
| 5 mM | 1.9395 mL | 9.6974 mL | 19.3949 mL | |
| 10 mM | 0.9697 mL | 4.8487 mL | 9.6974 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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