Zolmitriptan

Alias: 311C 90; Flezol; zolmitriptan; 311C90; 311 C90; trade names Zomig; Zomigon; AscoTop; Zomigoro

Cat No.:V0989 Purity: ≥98%

COA Product Data Instructions for use SDS

Zolmitriptan (311C90; 311 C90; trade names AscoTop, Zomig, Zomigon, Zomigoro), an approved drug for the treatment of acute migraines, is a potent and highly selective 5-HT(1B/1D) receptor agonist of the triptan class.

Zolmitriptan Chemical Structure CAS No.: 139264-17-8
Product category: 5-HT Receptor

This product is for research use only, not for human use. We do not sell to patients.

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Citations by Top Journals: Nature, Cell, Science, etc.

Top Publications Citing lnvivochem Products

Nature 2021, 597(7874):119-125.

Cell 2020,183:1202-1218.e25.

Science Adv 2022: 8, eabm9427.

Nature 597, 119–125 (2021)

Cell Stem Cell 2020,26(6):845-861.e12.

Science Trans Med 2023,15(701):eadd7872.

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Science Trans Med 2023, 15: eadd7872.

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J Am Chem Soc 2022,144:21831-21836.

Cell 2020,183:1202-1218.e25.

Science Adv 2022:8,eabm9427.

Nature 2021,597(7874):119-125.

Cell 2020,183:1202-1218.e25.

PNAS Nexus 2022,1(3):pgac063.

ACS Nano 2023,17(10):9110-9125.

Biomaterial 2023 Sep16:302:122333.

Purity & Quality Control Documentation

Current batch：

Purity: ≥98%

COA

MSDS

Instructions

Product Description
Bioactivity & Protocols
Physicochemical Properties
Solubility Data
Calculators
Clinical Trial Information

Product Description

Biological Activity I Assay Protocols (From Reference)

Targets

5-HT_1B Receptor ( IC50 = 5.01 nM ); 5-HT_1D Receptor ( IC50 = 0.63 nM ); 5-HT_1F Receptor ( IC50 = 63.09 nM ); Human Endogenous Metabolite

ln Vitro

In vitro activity: Zolmitriptan causes the human epicardial coronary artery rings and the primate basilar artery to contract in response to concentration. High affinity for human recombinant 5-HT1D (previously 5-HT1D alpha) and 5-HT1B (previously 5-HT1D beta) receptors is demonstrated by zolmitriptan in transfected CHO-K1 cell membranes.[1] With a pD(2) value of 7.03, zolmitriptan raises I(K) in C6 glioma cells expressing recombinant human 5-HT(1B) receptor in a concentration-dependent manner, reaching a maximum increase of 16.3%. When added to the patch pipette in C6 cells expressing cloned human 5-HT(1B) receptors, the calcium chelator EGTA (5 mM) inhibits zolmitriptan-induced increases in I(K).[2]

ln Vivo

Zolmitriptan (3-30 mg/kg, i.v.) administered ten minutes prior to unilateral electrical stimulation of the trigeminal ganglion results in a dose-dependent inhibition of [125I]-albumin extravasation within the ipsilateral dura mater in anaesthetized guinea-pigs.[1] Zolmitriptan (10-1000 mg/kg, i.v.) reduces arteriovenous-anastomotic (AVA) conductance in a targeted manner, with a maximum reduction of 92.5%. While zolmitriptan has no effect on cerebral conductance, it does produce a slight reduction in extra-cerebral conductance (maximum reduction of 23.9% at 30 mg/kg, i.v.). In anesthetized cats, zolmitriptan (1-30 mg/kg, intravenously) causes dose-dependent reductions in ear microvascular conductance (15% to 60%), which are mirrored by reductions in carotid arterial conductance.[3] In mice, zolmitriptan has anti-aggressive effects that are behaviorally specific. Moreover, zolmitriptan equally effectively reduces alcohol-induced aggression in mice.[4]

Animal Protocol

Anaesthetized guinea-pigs
0, 3, 10, 30 μg/kg
I.v.

References

[1]. Br J Pharmacol . 1997 May;121(2):157-64.

[2]. Eur J Pharmacol . 2000 Jun 2;397(2-3):297-302.

[3]. Eur J Pharmacol . 1998 Nov 20;361(2-3):191-7.

[4]. Psychopharmacology (Berl) . 2001 Sep;157(2):131-41.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Physicochemical Properties

Molecular Formula

C16H21N3O2

Molecular Weight

287.36

Exact Mass

287.17

Elemental Analysis

C, 66.88; H, 7.37; N, 14.62; O, 11.14

CAS #

139264-17-8

Related CAS #

139264-17-8

Appearance

Solid powder

SMILES

CN(C)CCC1=CNC2=C1C=C(C=C2)C[C@H]3COC(=O)N3

InChi Key

ULSDMUVEXKOYBU-ZDUSSCGKSA-N

InChi Code

InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1

Chemical Name

(4S)-4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one

Synonyms

311C 90; Flezol; zolmitriptan; 311C90; 311 C90; trade names Zomig; Zomigon; AscoTop; Zomigoro

HS Tariff Code

2934.99.9001

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Shipping Condition

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Solubility Data

Solubility (In Vitro)

DMSO: 58~100 mg/mL (201.8~348.0 mM)

Water: <1 mg/mL

Ethanol: ~58 mg/mL (~201.8 mM)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.4800 mL	17.3998 mL	34.7996 mL
	5 mM	0.6960 mL	3.4800 mL	6.9599 mL
	10 mM	0.3480 mL	1.7400 mL	3.4800 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Mass

Concentration

Volume

Molecular Weight*

Calculate Reset

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

Calculate the Mass of a compound required to prepare a solution of known volume and concentration
Calculate the Volume of solution required to dissolve a compound of known mass to a desired concentration
Calculate the Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?

Enter 350.26 in the Molecular Weight (MW) box
Enter 10 in the Concentration box and choose the correct unit (mM)
Enter 5 in the Volume box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

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Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:

Enter 10 into the Concentration (Start) box and choose the correct unit (mM)
Enter 25 into the Concentration (End) box and select the correct unit (mM)
Enter 25 into the Volume (End) box and choose the correct unit (mL)
Click the “Calculate” button
The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box

Molecular formula

Total molecular weight

g/mol

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Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4 c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter the chemical/molecular formula and click the “Calculate’ button.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

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Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

Enter the mass of the reagent and the desired reconstitution concentration as well as the correct units
Click the “Calculate” button
The answer appears in the Volume (to add to vial) box

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)

Dosage mg/kg

Average weight of animals g

Dosing volume per animal μL

Number of animals

Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)

% DMSO

% Tween 80

% ddH₂O

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Calculation results

Working concentration： mg/mL；

Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O，mix and clarify.

Note： (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

Clinical Trial Information

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05019430	Recruiting	Drug: Zolmitriptan Drug: Cocaine	Cocaine Use Disorder	William Stoops	October 15, 2021	Early Phase 1
NCT03145467	Completed	Drug: Paracetamol Drug: Zolmitriptan	Acute Migraine Headache	Pamukkale University	January 2016	Phase 4
NCT02745392	Completed	Drug: ZP-Zolmitriptan Drug: Placebo	Acute Migraine	Zosano Pharma Corporation	June 2016	Phase 2 Phase 3
NCT00637286	Completed	Drug: Zolmitriptan	Migraine	AstraZeneca	July 2004	Phase 4
NCT00617747	Completed	Drug: Zolmitriptan Drug: Placebo	Migraine	AstraZeneca	September 2002	Phase 3