| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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Purity: ≥98%
Zinc pyrithione (formerly known as OM-1563; AI3-62421; BCJ; BC-J OM1563; Biocut ZP, Finecide ZPT), an ingredient of commercial anti-dandruff shampoos, is an antifungal and antibacterial agent that disrupts membrane transport by blocking the proton pump. Zinc pyrithione is considered as a coordination complex of zinc structurally. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers.
| ln Vitro |
Zinc pyrithione is regarded as a zinc coordination complex. Formally monoanions, the pyrithione ligands are chelated to Zn 2+ through the action of sulfur and oxygen centers. Zinc pyrithione is found in crystal form as a centrosymmetric dimer, with each zinc linked to two sulfur and three oxygen atoms. Nonetheless, the dimers split apart in solution due to the scission of a single Zn-O link. The half-maximal effect (K1/2) of zinc pyrithione (a dimer that is likely biologically active as a monomer) is approximately 0.3 mM, and it causes plasma membrane depolarization[1]. Zinc Pyrithione (10 nM-10 μM; 72 hours) dramatically causes AAVS1 cell death[2].
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| ln Vivo |
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| References |
[1]. Ermolayeva, E. and D. Sanders, Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol, 1995. 61(9): p. 3385-90.
[2]. Peter Tsvetkov, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 Mar 18;375(6586):1254-1261. |
| Molecular Formula |
C10H8N2O2S2ZN
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| Molecular Weight |
317.7
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| CAS # |
13463-41-7
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| Related CAS # |
1121-31-9;
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| SMILES |
[Zn+2].[S-]C1=C([H])C([H])=C([H])C([H])=[N+]1[O-].[S-]C1=C([H])C([H])=C([H])C([H])=[N+]1[O-]
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1476 mL | 15.7381 mL | 31.4762 mL | |
| 5 mM | 0.6295 mL | 3.1476 mL | 6.2952 mL | |
| 10 mM | 0.3148 mL | 1.5738 mL | 3.1476 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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