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    Zinc Pyrithione (OM-1563)
    Zinc Pyrithione (OM-1563)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1636
    CAS #: 13463-41-7Purity ≥98%

    Description: Zinc pyrithione (also known as OM-1563), an ingredient of commercial anti-dandruff shampoos, is an antifungal and antibacterial agent that disrupts membrane transport by blocking the proton pump. Zinc pyrithione is considered as a coordination complex of zinc structurally. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. 

    References: Appl Environ Microbiol. 1995 Sep;61(9):3385-90; Environ Toxicol Chem. 2010 Nov;29(11):2583-92.

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    Molecular Weight (MW)317.7
    FormulaC10H8N2O2S2Zn
    CAS No.13463-41-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 30 mg/mL (94.4 mM)
    Water:<1 mg/mL
    Ethanol: <1 mg/mL
    Solubility (In vivo)

    Chemical Name: (T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc

    InChi Key: YZYHTCSREWDSOL-UHFFFAOYSA-O

    InChi Code: InChI=1S/C5H6NOS.C5H4NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h1-5,8H;1-4H;/q2*-1;+1/p+1

    SMILES Code: C1=CC2S=[Zn+2]3(S=C4C=CC=CN4[O-]3)[O-]N2C=C1

    SynonymsOM-1563; OM 1563; OM1563; AI3 62421, BC J, AI3-62421, BCJ, AI362421, BC-J, Biocut ZP, Finecide ZPT, Pyrithione zinc; Zinc pyrithione


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    In Vitro

    In vitro activity: Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential.

    In VivoZinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50) = 8.27 μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed. 
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    References

    Appl Environ Microbiol. 1995 Sep;61(9):3385-90; Environ Toxicol Chem. 2010 Nov;29(11):2583-92.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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