Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Purity: ≥98%
Targets |
GRP78 (IC50 = 1.5 μM)
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ln Vitro |
When compared to normal pancreas-derived HPNE cells (IC50>30 μM), YUM70 selectively cytotoxicly affects MIA PaCa-2, PANC-1, and BxPC-3 cells (IC50=2.8, 4.5, and 9.6 μM) [1]. In PaCa-2 cells, 5 μM for 24 hours causes endoplasmic reticulum (ER)-mediated MIA [1].
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ln Vivo |
Tumor growth in the MIA PaCa-2 xenograft model is inhibited by YUM70 (30 mg/kg; i.p., five times per week for seven weeks) [1]. Mice models show that YUM70 (15 mg/kg; intravenous administration) demonstrates t1/2 (1.40 h), CL (724.04 mL/h/kg), and Vss (1162.73 mL/kg) [1]. The model demonstrates low bioavailability (6.71%), t1/2 (2.74 h), and CL (9230.15 mL/h/kg) for YUM70 (30 mg/kg; oral) [1].
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Cell Assay |
Western Blot Analysis[1]
Cell Types: MIA PaCa-2, PANC-1 cells Tested Concentrations: 0.1, 1, 2.5, 5, 10 μM Incubation Duration: 2, 4, 8, 24, 48 hrs (hours) Experimental Results: At a certain dose and time Protein levels of FAM129A, DDIT3, CHAC-1, DDIT4, UPP1 and GRP78 were increased in a dependent manner. |
Animal Protocol |
Animal/Disease Models: 8weeks old female NCr nude mice were injected with MIA PaCa-2 cells [1]
Doses: 30 mg/kg Route of Administration: intraperitoneal (ip) injection 5 days per week for 7 weeks Experimental Results: Significant tumor growth was observed during treatment Delayed, no significant change in weight. |
References |
[1]. Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.
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Molecular Formula |
C21H19CLN2O4
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Molecular Weight |
398.843
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Exact Mass |
398.10
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Elemental Analysis |
C, 63.24; H, 4.80; Cl, 8.89; N, 7.02; O, 16.05
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CAS # |
423145-35-1
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Related CAS # |
423145-35-1
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Appearance |
Solid powder
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SMILES |
CCCC(=O)NC(C1=CC2=C(C=C1)OCO2)C3=CC(=C4C=CC=NC4=C3O)Cl
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InChi Key |
BIQMEYCMAGHOEQ-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C21H19ClN2O4/c1-2-4-18(25)24-19(12-6-7-16-17(9-12)28-11-27-16)14-10-15(22)13-5-3-8-23-20(13)21(14)26/h3,5-10,19,26H,2,4,11H2,1H3,(H,24,25)
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Chemical Name |
N-[1,3-benzodioxol-5-yl-(5-chloro-8-hydroxyquinolin-7-yl)methyl]butanamide
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Synonyms |
YUM-70; YUM70; YUM 70
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO 80~100 mg/mL (200.6~250.7 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (6.27 mM) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.5073 mL | 12.5364 mL | 25.0727 mL | |
5 mM | 0.5015 mL | 2.5073 mL | 5.0145 mL | |
10 mM | 0.2507 mL | 1.2536 mL | 2.5073 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
YUM70 is cytotoxic to pancreatic cancer cell lines. Cancer Res . 2021 Apr 1;81(7):1883-1895. td> |
YUM70 upregulates UPR target proteins and induces ER stress and apoptosis. Cancer Res . 2021 Apr 1;81(7):1883-1895. td> |
YUM70 upregulates proteins involved in the apoptotic pathway. Cancer Res . 2021 Apr 1;81(7):1883-1895. td> |
YUM70 targets GRP78. Cancer Res . 2021 Apr 1;81(7):1883-1895. td> |