Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Purity: ≥98%
WZ811 (WZ-811; WZ 811) is a highly potent, selective, competitive antagonist of CXCR4 chemokine receptor with potential anticancer activity. It has subnanomolar potency (EC50 = 0.3 nM) to inhibit CXCR4 in an affinity binding assay. WZ811 effectively blocks the modulation of cyclic adenosine monophophate (cAMP) levels (EC50 = 1.2 nM) and SDF-1-induced Matrigel invasion (EC50 = 5.2 nM) by CXCR4/stromal cell-derived factor-1 (SDF-1).
Targets |
CXCR4 ( EC50 = 0.3 nM )
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ln Vitro |
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ln Vivo |
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Cell Assay |
WZ811 is applied to cells and left for 24 hours at 37°C. Following the process of collection and washing with phosphate-buffered saline (PBS) buffer, the cells are reconstituted at a final density of 1 × 106/mL using staining buffer. Then, 100 μL cell suspensions are mixed with 5 μL annexin V-APC, and the mixture is incubated for 10 minutes at room temperature in the dark. Lastly, FACS Calibur is used to analyze the cell apoptosis profiles.
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Animal Protocol |
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References |
Molecular Formula |
C18H18N4
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Molecular Weight |
290.36
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Exact Mass |
290.15
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Elemental Analysis |
C, 74.46; H, 6.25; N, 19.30
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CAS # |
55778-02-4
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Related CAS # |
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Appearance |
White solid powder
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SMILES |
C1=CC=NC(=C1)NCC2=CC=C(C=C2)CNC3=CC=CC=N3
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InChi Key |
KBVFRXIGQQRMEF-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)
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Chemical Name |
N-[[4-[(pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
5%DMSO + 40%PEG300 + 5%Tween 80 + 50%ddH2O: 1.5mg/ml (5.17mM) (Please use freshly prepared in vivo formulations for optimal results.)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.4440 mL | 17.2200 mL | 34.4400 mL | |
5 mM | 0.6888 mL | 3.4440 mL | 6.8880 mL | |
10 mM | 0.3444 mL | 1.7220 mL | 3.4440 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.