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    InvivoChem Cat #: V0759
    CAS #: 1421227-53-3Purity ≥98%

    Description: WS6 (WS6; WS 6) is a novel and potent small molecule modulator of β cell proliferation via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway with important biological activity. WS6 is able to ameliorate diabetes, and induce concomitant increases in β cell proliferation and β cell number in RIP-DTA mouse model of β cell ablation. 

    References: J Am Chem Soc. 2013 Feb 6;135(5):1669-72.

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    Molecular Weight (MW)568.59
    CAS No.1421227-53-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (175.9 mM)
    Water: <1 mg/mL
    Ethanol: 100 mg/mL (175.9 mM)
    Other infoChemical Name: 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide
    InChi Code: InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3,6-9,15-16,18,20H,4-5,10-14,17H2,1H3,(H,35,39)(H,33,34,36,40)
    SMILES Code: O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3
    SynonymsWS-6; WS 6; WS6; 

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    In Vitro

    In vitro activity: WS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in rodent and human primary islets. Both Erb3 binding protein-1 and the IκB kinase pathway are confirmed to function in the mechanism of action of WS6.

    Cell Assay: R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells.

    In VivoIn RIP-DTA mouse model of β cell ablation, WS6 (50 mg/kg p.o.) ameliorates diabetes, and induces concomitant increases in β cell proliferation and β cell number
    Animal modelRIP-DTA mouse model
    Formulation & Dosage50 mg/kg; p.o.
    ReferencesJ Am Chem Soc. 2013 Feb 6;135(5):1669-72.

    These protocols are for reference only. InvivoChem does not independently validate these methods.

    J Am Chem Soc. 2013 Feb 6;135(5):1669-72.


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