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      WS3
      WS3

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      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V0758
      CAS #: 1421227-52-2Purity ≥98%

      Description: WS-3 (WS3; WS 3) is a novel and potent small molecule modulatior of Erb3 binding protein-1 (EBP1) and the IκB (IkappaB) kinase with important biological activity. It promotes β-cell proliferation with an EC50 of 28 nM (induced R7T1 proliferation). In HEK cells stably expressing either hTRPM8 or hTRPA1, WS 3 activated hTRPM8 and hTRPA1 with EC50 values of 2.2 and 120.6 μM, respectively. WS 3 was efficacious in eliciting cooling sensation.

      References: Chem Senses. 2011 Sep;36(7):649-58.; J Am Chem Soc. 2013 Feb 6;135(5):1669-72; ACS Chem Biol. 2013 Jul 19;8(7):1407-11. 

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      Molecular Weight (MW)569.58
      FormulaC28H30F3N7O3
      CAS No.1421227-52-2
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 100 mg/mL (175.6 mM)
      Water: <1 mg/mL
      Ethanol: 80 mg/mL warmed (140.5 mM)
      OtherChemical Name: N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide
      InChi Key: KIKOYRNAERIVSJ-UHFFFAOYSA-N
      InChi Code: InChI=1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29,30)31)35-27(40)34-20-6-8-22(9-7-20)41-25-15-24(32-17-33-25)36-26(39)18-2-3-18/h4-9,14-15,17-18H,2-3,10-13,16H2,1H3,(H2,34,35,40)(H,32,33,36,39)
      SMILES Code: CN1CCN(CC2=CC=C(NC(NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1
      SynonymsWS-3; WS 3; WS3; 


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      In Vitro

      In vitro activity: WS3 induces proliferation of the mouse β cell line R7T1 with EC50 of 0.074 μM. WS3 reversibly induces proliferation of primary fetal and adult human retinal pigment epithelial (RPE) cells.

      Cell Assay: R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells.

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      Formulation & Dosage
      References Chem Senses. 2011 Sep;36(7):649-58.; J Am Chem Soc. 2013 Feb 6;135(5):1669-72; ACS Chem Biol. 2013 Jul 19;8(7):1407-11. 

      These protocols are for reference only. InvivoChem does not independently validate these methods.

       

      WS3

      Proliferation of fetal human RPE cells grown in the presence of WS3. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. 
      		 
      WS3
      (A–B) WS3-expanded fetal human RPE cells grown in the presence of WS3 and differentiated for five weeks. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. 
      		 

      WS3

      Restoration of a functional RPE monolayer in RCS rats at P90 following transplantation of rat RPE cells expanded with WS3. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. 

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