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    WNK463
    WNK463

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3433
    CAS #: 2012607-27-9 Purity ≥98%

    Description: WNK463 (NVP-WNK463) is a novel, potent and orally bioavailable pan-WNK-kinase inhibitor with IC50s of 5, 1, 6, and 9 nM for WNK1, WNK 2, WNK 3, and WNK 4, respectively. The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and body fluid and electrolyte homeostasis. WNK463 exploits unique structural features of the WNK kinases for both affinity and kinase selectivity. In rodent models of hypertension, WNK463 affects blood pressure and body fluid and electro-lyte homeostasis, consistent with WNK-kinase-associated physiology and pathophysiology.

    References:  2016 Nov;12(11):896-898. 

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    WNK463

    Name: WNK463
    CAS#: 2012607-27-9
    Chemical Formula: C21H24F3N7O2
    Exact Mass: 463.1944
    Molecular Weight: 463.4652
    Elemental Analysis: C, 54.42; H, 5.22; F, 12.30; N, 21.16; O, 6.90
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: NVP-WNK463; NVP-WNK 463; NVP-WNK-463; WNK463; WNK-463; WNK 463.
    Chemical Name: N-tert-Butyl-3-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl]piperidin-4-yl]imidazole-4-carboxamide
    InChi Key: HWSHOMMVLGBIDN-UHFFFAOYSA-N
    InChi Code: InChI=1S/C21H24F3N7O2/c1-20(2,3)27-17(32)15-11-25-12-31(15)14-6-8-30(9-7-14)16-5-4-13(10-26-16)18-28-29-19(33-18)21(22,23)24/h4-5,10-12,14H,6-9H2,1-3H3,(H,27,32)
    SMILES Code: O=C(C1=CN=CN1C2CCN(C3=NC=C(C4=NN=C(C(F)(F)F)O4)C=C3)CC2)NC(C)(C)C


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