| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| Other Sizes |
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Purity: ≥98%
WAY-151932 (also known as VNA-932; WAY-VNA 932) is a novel and potent vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay. Small molecule agonists and antagonists of the V(2)-vasopressin receptor have been discovered and have undergone clinical trials.
| ln Vitro |
WAY-151932 (VNA-932) has an EC50 of 0.74±0.07 nM and dose-dependently induces cAMP production in LV2 cells expressing hV2 receptors [2].
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| ln Vivo |
Oral administration of WAY-151932 (VNA-932) to conscious rats loaded with water results in a rise in osmotic pressure and a dose-dependent decrease in urine production (ED50=0.14 mg/kg, 2.5% starch in water vehicle) without altering the excretion curve of urine electrolytes[2].
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| References |
[1]. Molinari AJ, et al. Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5796-800.
[2]. Failli AA, et al. Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9. |
| Molecular Formula |
C23H19N4OCL
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|---|---|
| Molecular Weight |
402.87616
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| CAS # |
220460-92-4
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| SMILES |
O=C(C1=CC=C(N2N=C(C)C=C2)C=C1Cl)C3=C4C(NCC5=CC=CN53)=CC=CC4
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| InChi Key |
VLENVJZOHAXBBV-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C23H19ClN4O/c1-15-10-12-28(26-15)16-8-9-18(20(24)13-16)23(29)22-19-6-2-3-7-21(19)25-14-17-5-4-11-27(17)22/h2-5,7-13,25H,6,14H2,1H3
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| Chemical Name |
[2-chloro-4-(3-methylpyrazol-1-yl)phenyl]-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepin-5-yl)methanone
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| Synonyms |
VNA932, VNA 932, VNA-932; VNA-932; WAY-VNA 932; WAY-VNA-932; WAY VNA 932; WAY VNA-932; WAYVNA 932
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~200 mg/mL (~496.43 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (12.41 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (12.41 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 5 mg/mL (12.41 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4821 mL | 12.4106 mL | 24.8213 mL | |
| 5 mM | 0.4964 mL | 2.4821 mL | 4.9643 mL | |
| 10 mM | 0.2482 mL | 1.2411 mL | 2.4821 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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