| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| References |
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| Additional Infomation |
Vocamine is a citrate acyl compound. Vocamine is an alkaloid isolated from the bark of the African rosewood (Pescheria fuchsiae folia). It is an antimalarial drug approved for use in several African countries. Its application in regulating multidrug resistance in tumor cells is also currently under investigation. Vocamine has been reported to be found in Tabernaemontana pachysiphon, Tabernaemontana hystrix, and other organisms with relevant data. Drug Indications: Used for the treatment of malaria. Its application in regulating multidrug resistance in cancer cells is also currently under investigation. Mechanism of Action: Vocamine may be a substrate of P-glycoprotein (P-gp), an efflux pump responsible for multidrug resistance in tumor cells. Voacamine may compete with anticancer drugs such as doxorubicin for P-gp transport, thereby reducing the clearance rate of doxorubicin.
Pharmacodynamics Voacamine is an antimalarial drug extracted from the Brazilian tree Peschiera fuchsiaefolia. In a study (PMID: 11180519), researchers evaluated the in vivo antimalarial activity of voacamine in a 4-day trial. Results showed that at doses of 2.5 mg/kg and 10 mg/kg, voacamine inhibited parasitemia by 25.4% and 43.4%, respectively. In simultaneous cultures, researchers found that voacamine had effects on both the trophozoite and schizont stages of Plasmodium falciparum. Voacamine is a bisindole alkaloid, and its modulatory effects on multidrug resistance are currently being investigated to enhance the efficacy of anticancer drugs such as doxorubicin. |
| Molecular Formula |
C43H52N4O5
|
|---|---|
| Molecular Weight |
704.89678
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| Exact Mass |
704.394
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| Elemental Analysis |
C, 69.32; H, 8.64; N, 2.45; O, 19.59
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| CAS # |
3371-85-5
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| PubChem CID |
11953931
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| Appearance |
White to off-white solid powder
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| Density |
1.309g/cm3
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| Melting Point |
223℃
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| Index of Refraction |
1.674
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| LogP |
6.364
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
52
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| Complexity |
1410
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| Defined Atom Stereocenter Count |
7
|
| SMILES |
CCC1CC2CC3(C1N(C2)CCC4=C3NC5=CC(=C(C=C45)OC)C6CC7C(C(CC8=C6NC9=CC=CC=C89)N(CC7=CC)C)C(=O)OC)C(=O)OC
|
| InChi Key |
VCMIRXRRQJNZJT-XRMSBCOFSA-N
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| InChi Code |
InChI=1S/C43H52N4O5/c1-7-24-15-23-20-43(42(49)52-6)39-27(13-14-47(21-23)40(24)43)29-19-36(50-4)30(17-34(29)45-39)31-16-28-25(8-2)22-46(3)35(37(28)41(48)51-5)18-32-26-11-9-10-12-33(26)44-38(31)32/h8-12,17,19,23-24,28,31,35,37,40,44-45H,7,13-16,18,20-22H2,1-6H3/b25-8-/t23-,24-,28-,31+,35+,37?,40-,43+/m0/s1
|
| Chemical Name |
methyl (1S,15S,17S,18S)-17-ethyl-6-[(1R,12R,14R,15E)-15-ethylidene-18-methoxycarbonyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraen-12-yl]-7-methoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate
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| Synonyms |
Veratramine 3-O-glucoside; Veratrosine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~141.86 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (3.55 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (3.55 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4186 mL | 7.0932 mL | 14.1864 mL | |
| 5 mM | 0.2837 mL | 1.4186 mL | 2.8373 mL | |
| 10 mM | 0.1419 mL | 0.7093 mL | 1.4186 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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