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    Vinpocetine (RGH-4405; AY-27,255)
    Vinpocetine (RGH-4405; AY-27,255)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1662
    CAS #: 42971-09-5Purity ≥98%

    Description: Vinpocetine (also known as RGH-4405; AY-27,255; Ethyl apovincaminate),  a synthetic derivative of the vinca alkaloid vincamine extracted from the lesser periwinkle plant, is a novel, potent and selective voltage-sensitive sodium channel blocker for the treatment of stroke, vascular dementia and Alzheimer's disease. Vinpocetine has been reported to have a selective and noncompetitive inhibition of Ca2+ PDE and thus regulate cyclic GMP levels in smooth muscle. In addition, vinpocetine has been revealed to inhibit the activities of three resolvable PDE in the cytosol of rat aorta with Ki values of 14±2μM, >1000μM and >1000μM for Ca2+ PDE(+)CaM, cGMP PDE and cAMP PDE, respectively. 

    References: Brain Res Bull. 2000 Oct;53(3):245-54; Br J Pharmacol. 1989 Nov;98(3):725-34.

    Related CAS#: 1617-90-9 (vincamine)

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    Molecular Weight (MW)350.45 
    FormulaC22H26N2O2 
    CAS No.42971-09-5  (Vinpocetine);
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 3 mg/mL (8.6 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL 
    Other info
    Chemical Name: ethyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
    InChi Key: DDNCQMVWWZOMLN-IRLDBZIGSA-N
    InChi Code: InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1
    SMILES Code: O=C(C1=C[[email protected]@](CCC2)(CC)[[email protected]]3([H])N2CCC4=C3N1C5=C4C=CC=C5)OCC 
    SynonymsRGH-4405; apovincaminic acid ethyl ester, ethyl apovincaminate, AY 27,255, AY-27,255, RGH 4405, RGH4405, TCV-3B, TCV 3B, TCV3B, Cavinton, Intelectol


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    In Vitro

    In vitro activity: Vinpocetine has been reported to have a selective and noncompetitive inhibition of Ca2+ PDE and thus regulate cyclic GMP levels in smooth muscle. In addition, vinpocetine has been revealed to inhibit the activities of three resolvable PDE in the cytosol of rat aorta with Ki values of 14±2μM, >1000μM and >1000μM for Ca2+ PDE(+)CaM, cGMP PDE and cAMP PDE, respectively.


    Cell Assay: Vinpocetine (Cavinton; Ethyl apovincaminate) is a selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels. 

    In VivoVinpocetine has shown the potent inhibition of 5-HT-induced contractions in endothelium-intact rat aorta with an EC50 value of 1μM. 
    Animal modelRats
    Formulation & DosageN/A
    ReferencesBr J Pharmacol. 1989 Nov;98(3):725-34. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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