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    Trospium chloride
    Trospium chloride

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1170
    CAS #: 10405-02-4 Purity ≥98%

    Description: Trospium chloride (IP-631; IP 631;Sanctura; Trosec; Regurin; Flotros; Tropez OD; Spasmex; Spasmoly) is a potent and competitive muscarinic cholinergic receptor antagonist and a medication used to treat overactive bladder. It antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder. Receptor assays showed that trospium chloride has negligible affinity for nicotinic receptors as compared to muscarinic receptors at concentrations obtained from therapeutic doses. 

    References: Int J Clin Pract. 2010 Oct;64(11):1535-40; Ann Pharmacother. 2009 Feb;43(2):283-95. 

    Related CAS#: 47608-32-2 (Trospium)

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    Molecular Weight (MW)427.96 
    CAS No.10405-02-4 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 41 mg/mL (95.8 mM) 
    Water: 86 mg/mL (201 mM)
    Ethanol: 42 mg/mL (98.1 mM)
    SMILES O=C(C(C1=CC=CC=C1)(O)C2=CC=CC=C2)O[[email protected]@H]3C[[email protected]]([N+]45CCCC4)CC[[email protected]]5C3.[Cl-]
    Synonyms IP631; Trospium chloride, IP-631; IP 631; trade name Sanctura; Tropez OD; Trosec; Regurin; Flotros; Spasmex; Spasmoly.

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    In Vitro

    In vitro activity: Trospium Chloride is a competitive muscarinic cholinergic receptor antagonist. Target: mAChR Trospium chloride is an antimuscarinic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. 

    In VivoTrospium has pharmacologic properties that are distinct from other antimuscarinic agents. After oral administration, absorption of the hydrophilic trospium chloride is slow and incomplete. Peak plasma concentrations (Cmax) of approximately 4 ng/mL are reached 4-5 hours after administration of a 20 mg immediate-release preparation. The mean bioavailability is approximately 10% and decreases by concomitant food intake (to a mean of 26% of the fasting area under the plasma concentration-time curve [AUC]). Trospium chloride displays dose proportional increases in AUC and Cmax after a single dose within the clinically relevant dose range (20-60 mg). The mean volume of distribution is approximately 350-800 L.
    Animal model Mice PK model
    Formulation & Dosage 20-60 mg
    References Urol Clin North Am, 2006. 33(4): p. 465-73, viii.

    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Trospium chloride
    Kaplan–Meier plots of persistence with antimuscarinic drugs for the treatment of overactive bladder. Int J Clin Pract. 2010 Oct;64(11):1535-40.


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