| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| Other Sizes |
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| ln Vivo |
In a model of chemically induced articular cartilage injury, trimetinide acetonide significantly protects the injured tissue at different dosages. Triamcinolone acetonide injections resulted in less noticeable osteophytes and tremors in guinea pigs. Less cell loss. In rabbits that had undergone partial lateral meniscectomy and transection of the sesamoid and fibular collateral ligaments, a single injection of triamcinolone acetonide into the ipsilateral knee decreased chondrocyte cloning, cell death, osteophyte formation, and fibrillation[1]. Commercially available triamcinolone acetonide has a twice-as-long half-life in the vitreous as does triamcinolone acetonide; yet, in this rabbit model, the former proved hazardous to the retina. There is no proof that reformulated isotonic triamcinolone acetonide negatively affects retinal structure or function [2]. When triamcinolone acetonide is applied topically to the site of lingual nerve injury, it can lead to positive changes like improved regeneration and decreased mechanical sensitivity [3].
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| References |
[1]. Williams JM, et al. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum. 1985 Nov;28(11):1267-74.
[2]. Abd-El-Barr MM, et al. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr;24(2):197-205. [3]. Yates JM, et al. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain. 2004 Oct;111(3):261-9 |
| Additional Infomation |
Triamcinolone hexacetonide is a corticosteroid hormone.
Triamcinolone Hexacetonide is the hexacetonide salt form of triamcinolone, a synthetic glucocorticosteroid with immunosuppressive and anti-inflammatory activity. Triamcinolone hexacetonide binds to specific cytosolic glucocorticoid receptors and subsequently interacts with glucocorticoid receptor response element on DNA and alters gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. See also: Triamcinolone Acetonide (has active moiety). |
| Molecular Formula |
C30H41FO7
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|---|---|
| Molecular Weight |
532.64
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| Exact Mass |
532.284
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| CAS # |
5611-51-8
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| Related CAS # |
76-25-5 (acetonide);124-94-7 (free);67-78-7 (diacetate);5611-51-8 (hexacetonide);
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| PubChem CID |
21826
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.24 g/cm3
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| Boiling Point |
619.5ºC
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| Flash Point |
328.5ºC
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| Index of Refraction |
1.556
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| LogP |
4.405
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
38
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| Complexity |
1130
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| Defined Atom Stereocenter Count |
8
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| SMILES |
O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](CCC3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C5)(OC(C)(C)O1)[C@]25C)COC(CC(C)(C)C)=O
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| InChi Key |
TZIZWYVVGLXXFV-FLRHRWPCSA-N
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| InChi Code |
InChI=1S/C30H41FO7/c1-25(2,3)15-24(35)36-16-22(34)30-23(37-26(4,5)38-30)13-20-19-9-8-17-12-18(32)10-11-27(17,6)29(19,31)21(33)14-28(20,30)7/h10-12,19-21,23,33H,8-9,13-16H2,1-7H3/t19-,20-,21-,23+,27-,28-,29-,30+/m0/s1
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| Chemical Name |
[2-[(1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 3,3-dimethylbutanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~41.67 mg/mL (~78.23 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (3.91 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8774 mL | 9.3872 mL | 18.7744 mL | |
| 5 mM | 0.3755 mL | 1.8774 mL | 3.7549 mL | |
| 10 mM | 0.1877 mL | 0.9387 mL | 1.8774 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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