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    Triamcinolone Acetonide
    Triamcinolone Acetonide

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1710
    CAS #: 76-25-5 Purity ≥98%

    Description: Triamcinolone acetonide is a potent and synthetic glucocorticoid with improved activities and is used in the symptomatic treatment of inflammation. Triamcinolone Acetonide significantly decreases the paracellular permeability of ECV304 cells and down-regulated ICAM-1 expression, consistent with immunocytochemical observations. Triamcinolone reverses the osmotic swelling of glial cells in retinas of the rat that is observed under various experimental conditions.

    References: Clin Exp Immunol. 2000 Sep;121(3):458-65; J Pharmacol Exp Ther. 2005 Dec;315(3):1036-45.

    Related CAS #: 67-78-7 (diacetate)   76-25-5 (acetonide)   124-94-7 (free)   5611-51-8 (hexacetonide)  

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    Molecular Weight (MW)434.5 
    FormulaC24H31FO6 
    CAS No.76-25-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 87 mg/mL (200.2 mM)
    Water: <1 mg/mL
    Ethanol: 13 mg/mL (29.9 mM) 
    Other info

    Chemical Name: (6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-6b-fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one

    InChi Key: YNDXUCZADRHECN-JNQJZLCISA-N

    InChi Code: InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1

    SMILES Code: C[[email protected]@]12[[email protected]@]3(C(CO)=O)[[email protected]](OC(C)(O3)C)C[[email protected]@]1([H])[[email protected]]4([H])CCC5=CC(C=C[[email protected]]5(C)[[email protected]@]4(F)[[email protected]@H](O)C2)=O

    Synonyms

    Acetospan; Adcortyl A; AllerNaze; Kenalone; Nasacort; Aristocort. Aristocort A. Aristocort acetonide. Aristoderm. Aristogel.


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    In Vitro

    In vitro activity: Triamcinolone Acetonide significantly decreases the paracellular permeability of ECV304 cells and down-regulated ICAM-1 expression, consistent with immunocytochemical observations. [1] Triamcinolone reverses the osmotic swelling of glial cells in retinas of the rat that is observed under various experimental conditions: in retinas isolated at 3 days after transient retinal ischemia, in retinas of eyes with lipopolysaccharide-induced ocular inflammation, and in control retinas in the presence of Ba2+ (1 mM), H2O2 (200 mM), arachidonic acid (10 mM), or prostaglandin E2 (30 nM). [2] Triamcinolone Acetonide reduces GAG synthesis compared to control and IL-1 alone. Triamcinolone Acetonide increases GAG degradation. Triamcinolone Acetonide increases media GAG content compared to control and IL-1 explants.

    In VivoTriamcinolone Acetonide (TAC), a synthetic glucocorticoid, induces cleft palate resulting from poor development of palatal shelves in mice. Triamcinolone Acetonide inhibits the proliferation of mesenchymal cells and affects the differentiation of MEE cells into stratified squamous epithelia in the palatal shelves of rat embryos. Triamcinolone Acetonide reduces lameness, edema, and concentration of synovial fluid protein after the second LPS injection in horse. Triamcinolone Acetonide also induces higher WBC counts and mepivacaine concentrations in synovial fluid, compared with results for Mepivacaine alone. 
    Animal modelMice
    Formulation & DosageN/A
    References

    Clin Exp Immunol. 2000 Sep;121(3):458-65; J Pharmacol Exp Ther. 2005 Dec;315(3):1036-45; J Vet Med Sci. 2004 Apr;66(4):397-402. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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