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      Tetrahydropapaverine HCl
      Tetrahydropapaverine HCl

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V0935
      CAS #: 6429-04-5Purity ≥98%

      Description: Tetrahydropapaverine (also known as Norlaudanosine HCl), one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons. Tetrahydropapaverine inhibits serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells with an IC50 of 7.5 μM and reduces tryptophan hydroxylase activity with an IC50 of 5.7 μM.

      References: Life Sci. 2004 Sep 3;75(16):1949-57; Brain Res. 1997 Apr 18;754(1-2):260-8.

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      Molecular Weight (MW)379.88
      FormulaC20H25NO4.HCl
      CAS No.6429-04-5
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 76 mg/mL (200.1 mM)
      Water: <1 mg/mL
      Ethanol: 7 mg/mL (18.4 mM)
      SMILES CodeCOC1=C(C=C(C=C1)CC2C3=CC(=C(C=C3CCN2)OC)OC)OC.Cl
      SynonymsNorlaudanosine HCl; Tetrahydropapaverine


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      In Vitro

      In vitro activity: Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons. Tetrahydropapaverine inhibits serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells with an IC50 of 7.5 μM and reduces tryptophan hydroxylase activity with an IC50 of 5.7 μM.

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      References

      Life Sci. 2004 Sep 3;75(16):1949-57; Brain Res. 1997 Apr 18;754(1-2):260-8.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

      Tetrahydropapaverine HCl

      Brain Res. 1997 Apr 18;754(1-2):260-8.
             		 

      Tetrahydropapaverine HCl

      Brain Res. 1997 Apr 18;754(1-2):260-8.

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