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    Tetrahydropapaverine HCl
    Tetrahydropapaverine HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0935
    CAS #: 6429-04-5Purity ≥98%

    Description: Tetrahydropapaverine (also known as Norlaudanosine HCl), one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons. Tetrahydropapaverine inhibits serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells with an IC50 of 7.5 μM and reduces tryptophan hydroxylase activity with an IC50 of 5.7 μM.

    References: Life Sci. 2004 Sep 3;75(16):1949-57; Brain Res. 1997 Apr 18;754(1-2):260-8.

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    Molecular Weight (MW)379.88
    FormulaC20H25NO4.HCl
    CAS No.6429-04-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 76 mg/mL (200.1 mM)
    Water: <1 mg/mL
    Ethanol: 7 mg/mL (18.4 mM)
    SMILES CodeCOC1=C(C=C(C=C1)CC2C3=CC(=C(C=C3CCN2)OC)OC)OC.Cl
    SynonymsNorlaudanosine HCl; Tetrahydropapaverine


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    In Vitro

    In vitro activity: Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons. Tetrahydropapaverine inhibits serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells with an IC50 of 7.5 μM and reduces tryptophan hydroxylase activity with an IC50 of 5.7 μM.

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    References

    Life Sci. 2004 Sep 3;75(16):1949-57; Brain Res. 1997 Apr 18;754(1-2):260-8.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Tetrahydropapaverine HCl

    Brain Res. 1997 Apr 18;754(1-2):260-8.
     
     

    Tetrahydropapaverine HCl

    Brain Res. 1997 Apr 18;754(1-2):260-8.


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