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    TCS JNK 5a
    TCS JNK 5a

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0473
    CAS #: 312917-14-9Purity ≥98%

    Description: TCS JNK 5a (also known as JNK Inhibitor IX; TCS JNK-5a) is a novel, highly selective and potent JNK (c-Jun N-terminal Kinase) inhibitor with potential antineoplastic activity. It inhibits JNK2/3 with pIC50 values of 6.5 and 6.7, respectively. It has no/little effects against EGFR, ErbB2, VegFr2, Src, Tie-2, Alk5, c-Fms, CDK-2, GSK3β and PLK1 with pIC50 values of < 5.0. Exposure of human Jurkat T cells to SC-202671 targeting JNK2 and JNK3, caused apoptotic DNA fragmentation along with G2/M arrest, phosphorylation of Bcl-2, Mcl-1, and Bim, Δψm loss, and activation of Bak and caspase cascade. 

    References: Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.

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    Molecular Weight (MW)332.42
    FormulaC20H16N2OS
    CAS No.312917-14-9
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO:20 mg/mL (60.2 mM)
    Water: <1 mg/mL
    Ethanol:<1 mg/mL
    Other info

    Chemical Name: N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide

    InChi Key: WQGDQGAFSDMBLA-UHFFFAOYSA-N

    InChi Code: InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)

    SMILES Code: O=C(C1=CC=CC2=CC=CC=C21)NC(S3)=C(C#N)C4=C3CCCC4

    Synonyms

    SC202671, JNK Inhibitor-IX, TCS-JNK-5a, TCS JNK 5a, JNK Inhibitor IX, SC-202671, SC 202671, 


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    In Vitro

    In vitro activity: JNK inhibitor IX significantly reduces caspase-3 activity by the inhibition of JNK activity in human dermal fibroblasts. JNK inhibition by JNK inhibitor IX significantly increases apoptotic death in response to imatinib mesylate (IM) by preventing c-ABL complete de-phosphorylation at Ser residues.


    Kinase Assay: TCS JNK 5a is a selective JNK2 and JNK3 inhibitor. TCS JNK 5a exhibited selective against JNK1 and p38α with pIC50 values of 6.7, 6.5,<5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α, respectively. Also, TCS JNK 5a was inactive at EGFR, ErbB2, VegFr2, Src, Tie-2, Alk5, c-Fms, CDK-2, GSK3β and PLK1 with pIC50 values of < 5.0.

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    References

    Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301; Toxicol Lett. 2009 Aug 10;188(3):236-42. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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