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Purity: ≥98%
Tariquidar dimesylate (formerly known as XR9576; D06008; XR-9576; D-06008), the dimesylate salt of Tariquidar, is a novel potent and selective noncompetitive inhibitor of P-glycoprotein (P-gp) with potential antitumor activity. It inhibits P-gp with a Kd of 5.1 nM in CHrB30 cells, and is able to reverse drug resistance in MDR cell Lines. Tariquidar is currently undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity.
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References |
Br J Pharmacol.1999 Sep;128(2):403-11;Cancer Res.2001 Jan 15;61(2):749-58.
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Molecular Formula |
C40H46N4O12S2
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Molecular Weight |
838.94
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CAS # |
625375-84-0
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Related CAS # |
206873-63-4;625375-84-0 (mesylate);
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SMILES |
S(C)(=O)(=O)O.S(C)(=O)(=O)O.O(C)C1C(=CC2=C(C=1)CN(CCC1C=CC(=CC=1)NC(C1=CC(=C(C=C1NC(C1=CN=C3C=CC=CC3=C1)=O)OC)OC)=O)CC2)OC
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.1920 mL | 5.9599 mL | 11.9198 mL | |
5 mM | 0.2384 mL | 1.1920 mL | 2.3840 mL | |
10 mM | 0.1192 mL | 0.5960 mL | 1.1920 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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