| Size | Price | Stock | Qty |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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Purity: ≥98%
Tanshinone IIA (Tan IIA; Dan Shen ketone), derived from phenanthrene-quinone, which is isolated from Salvia miltiorrhiza BUNGE. In these countries, it is traditionally used in herbal medicine to treat arthritis and rheumatism. Its ability to relieve other types of pain is restricted, though. Sinomenine is a derivative of morphinan that is connected to non-opioid cough suppressants like dextromethorphan and opioids like levorphanol.
| Targets |
VEGF/VEGFR2
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|---|---|
| ln Vitro |
Tanshinone IIA (Tanshinone B) is the most prevalent diterpene quinone in Danshen, where Salviae miltiorrhizae Radix is a commonly prescribed traditional herbal remedy used to treat inflammatory and cardiovascular conditions. Heart myocytes are shielded from oxidative stress-induced apoptosis by tanshinone IIA. The prevention of lipid peroxidation, enhanced scavenging of oxygen free radicals, and upregulation of the Bcl-2/Bax ratio all contribute to the in vivo protection.[1] It has recently been shown that tanshinone IIA can cause apoptosis and cell death in a range of tumor types.[2]
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| ln Vivo |
LD50: Rats 25g/kg (i.g.) [3]
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| Animal Protocol |
Male ICR mice (25–30 g)[4]
10 or 20 mg/kg P.o. |
| References | |
| Additional Infomation |
1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione is an abietane diterpenoid.
Tanshinone IIA has been reported in Salvia miltiorrhiza, Salvia glutinosa, and other organisms with data available. See also: Salvia Miltiorrhiza Root (part of). Mechanism of Action Doxorubicin, one of the original anthracyclines, remains among the most effective anticancer drugs ever developed. Clinical use of doxorubicin is, however, greatly limited by its serious adverse cardiac effects that may ultimately lead to cardiomyopathy and heart failure. Tanshinone IIA is the main effective component of Salvia miltiorrhiza known as 'Danshen' in traditional Chinese medicine for treating cardiovascular disorders. The objective of this study was set to evaluate the protective effect of tanshinone IIA on doxorubicin-induced cardiomyocyte apoptosis, and to explore its intracellular mechanism(s). Primary cultured neonatal rat cardiomyocytes were treated with the vehicle, doxorubicin (1 uM), tanshinone IIA (0.1, 0.3, 1 and 3 uM), or tanshinone IIA plus doxorubicin. /The authors/ found that tanshinone IIA (1 and 3 uM) inhibited doxorubicin-induced reactive oxygen species generation, reduced the quantity of cleaved caspase-3 and cytosol cytochrome c, and increased BcL-x(L) expression, resulting in protecting cardiomyocytes from doxorubicin-induced apoptosis. In addition, Akt phosphorylation was enhanced by tanshinone IIA treatment in cardiomyocytes. The wortmannin (100 nM), LY294002 (10 nM), and siRNA transfection for Akt significantly reduced tanshinone IIA-induced protective effect. These findings suggest that tanshinone IIA protects cardiomyocytes from doxorubicin-induced apoptosis in part through Akt-signaling pathways, which may potentially protect the heart from the severe toxicity of doxorubicin. |
| Molecular Formula |
C19H18O3
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|---|---|---|
| Molecular Weight |
294.3444
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| Exact Mass |
294.125
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| CAS # |
568-72-9
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| Related CAS # |
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| PubChem CID |
164676
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| Appearance |
Pink to red solid
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
480.7±44.0 °C at 760 mmHg
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| Melting Point |
205-207ºC
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| Flash Point |
236.4±21.1 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.588
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| LogP |
5.47
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
22
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| Complexity |
509
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O1C([H])=C(C([H])([H])[H])C2C(C(C3=C(C1=2)C([H])=C([H])C1=C3C([H])([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])=O)=O
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| InChi Key |
HYXITZLLTYIPOF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
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| Chemical Name |
1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product is not stable in solution, please use freshly prepared working solution for optimal results. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
5% DMSO+30% PEG 300+2% Tween 80+ddH2O: 0.2mg/mL (Please use freshly prepared in vivo formulations for optimal results.)
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3974 mL | 16.9872 mL | 33.9743 mL | |
| 5 mM | 0.6795 mL | 3.3974 mL | 6.7949 mL | |
| 10 mM | 0.3397 mL | 1.6987 mL | 3.3974 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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