| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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Purity: ≥98%
Tanshinone IIA (Tan IIA; Dan Shen ketone), derived from phenanthrene-quinone, which is isolated from Salvia miltiorrhiza BUNGE. In these countries, it is traditionally used in herbal medicine to treat arthritis and rheumatism. Its ability to relieve other types of pain is restricted, though. Sinomenine is a derivative of morphinan that is connected to non-opioid cough suppressants like dextromethorphan and opioids like levorphanol.
| Targets |
VEGF/VEGFR2
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|---|---|
| ln Vitro |
Tanshinone IIA (Tanshinone B) is the most prevalent diterpene quinone in Danshen, where Salviae miltiorrhizae Radix is a commonly prescribed traditional herbal remedy used to treat inflammatory and cardiovascular conditions. Heart myocytes are shielded from oxidative stress-induced apoptosis by tanshinone IIA. The prevention of lipid peroxidation, enhanced scavenging of oxygen free radicals, and upregulation of the Bcl-2/Bax ratio all contribute to the in vivo protection.[1] It has recently been shown that tanshinone IIA can cause apoptosis and cell death in a range of tumor types.[2]
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| ln Vivo |
LD50: Rats 25g/kg (i.g.) [3]
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| Animal Protocol |
Male ICR mice (25–30 g)[4]
10 or 20 mg/kg P.o. |
| References |
| Molecular Formula |
C19H18O3
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|---|---|---|
| Molecular Weight |
294.34
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| Exact Mass |
294.125594432
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| CAS # |
568-72-9
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| Related CAS # |
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| Appearance |
Solid
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| SMILES |
CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
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| InChi Key |
HYXITZLLTYIPOF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
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| Chemical Name |
1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
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| Synonyms |
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product is not stable in solution, please use freshly prepared working solution for optimal results. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
5% DMSO+30% PEG 300+2% Tween 80+ddH2O: 0.2mg/mL (Please use freshly prepared in vivo formulations for optimal results.)
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3974 mL | 16.9872 mL | 33.9743 mL | |
| 5 mM | 0.6795 mL | 3.3974 mL | 6.7949 mL | |
| 10 mM | 0.3397 mL | 1.6987 mL | 3.3974 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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