| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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Purity: ≥98%
Tangeretin (also called Tangeritin; NSC53909; NSC618905), a naturally occuring flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor. Recent studies have shown that tangeretin exhibits anti-proliferative, anti-invasive, anti-metastatic, and antioxidant activities. Tangeretin at 2.7 μM induces apoptosis in human promyelocytic leukaemia HL-60 cells, whereas the flavone showed no cytotoxicity against human peripheral blood mononuclear cells (PBMCs). Further study shows that tangeretin at 50 μM exerts its growth-inhibitory effects through modulation of the activities of several key G1 regulatory proteins such as Cdk2 and Cdk4, and mediates the increase of Cdk inhibitors p21 and p27.
| ln Vitro |
As demonstrated by MTT and colony formation experiments, tangeretin increased GC cells' radiosensitivity. Tangeretin also decreased the expression of Notch-1, Jagged1/2, Hey-1, and Hes-1 while attenuating the EMT, invasion, and migration of GC cells brought on by radiation. Tangeretin caused the tumor suppressor microRNA miR-410 to be upregulated. Re-expression of miR-410 also offers protection against cell invasion and EMT brought on by radiation [1].
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| ln Vivo |
In this work, the scientists evaluated the anti-RSV activity of Tangeretin in 3-week-old male BALB/c mice. Plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) indicated that Tangeretin can decrease RSV replication in mouse lungs [2].
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| Animal Protocol |
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| ADME/Pharmacokinetics |
Metabolism / Metabolites
Tangeretin has known human metabolites that include 5,6-Dihydroxy-7,8,4'-trimethoxyflavone and 4'-Hydroxy-5,6,7,8-tetramethoxyflavone. |
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| References |
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| Additional Infomation |
Tangeretin is a pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8. It has a role as an antineoplastic agent and a plant metabolite.
Tangeretin has been reported in Camellia sinensis, Citrus leiocarpa, and other organisms with data available. See also: Flavone (subclass of); Tangerine peel (part of); Citrus aurantium fruit rind (part of). |
| Molecular Formula |
C20H20O7
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|---|---|---|
| Molecular Weight |
372.37
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| Exact Mass |
372.12
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| CAS # |
481-53-8
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| Related CAS # |
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| PubChem CID |
68077
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| Appearance |
Off-white to yellow solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
565.3±50.0 °C at 760 mmHg
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| Melting Point |
155 °C
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| Flash Point |
248.4±30.2 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
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| Index of Refraction |
1.566
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| LogP |
2.66
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
27
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| Complexity |
540
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ULSUXBXHSYSGDT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
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| Chemical Name |
5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.71 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6855 mL | 13.4275 mL | 26.8550 mL | |
| 5 mM | 0.5371 mL | 2.6855 mL | 5.3710 mL | |
| 10 mM | 0.2686 mL | 1.3428 mL | 2.6855 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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